Concerted expression of eotaxin-1, eotaxin-2, and eotaxin-3 in human bronchial epithelial cells

被引：108

作者：

Komiya, A

Nagase, H

Yamada, H

Sekiya, T

Yamaguchi, M

Sano, Y

Hanai, N

Furuya, A

Ohta, K

Matsushima, K

Yoshie, O

Yamamoto, K

Hirai, K

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Bioregulatory Funct, Bunkyo Ku, Tokyo 1138655, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Allergy Rheumatol, Bunkyo Ku, Tokyo 1138655, Japan

[3] Univ Tokyo, Grad Sch Med, Dept Resp Med, Bunkyo Ku, Tokyo 1138655, Japan

[4] Doai Mem Hosp, Div Allergy & Resp Med, Sumida Ku, Tokyo 1308587, Japan

[5] Kyowa Hakko Kogyo Co Ltd, Tokyo Res Labs, Machida, Tokyo 1948533, Japan

[6] Teikyo Univ, Sch Med, Dept Internal Med, Itabashi Ku, Tokyo 1738605, Japan

[7] Univ Tokyo, GRad Sch Med, Dept Mol Prevent Med, Bunkyo Ku, Tokyo 1138655, Japan

[8] Kinki Univ, Sch Med, Dept Bacteriol, Osaka 5890014, Japan

来源：

CELLULAR IMMUNOLOGY | 2003年 / 225卷 / 02期

关键词：

asthma; CCR3; chemokines; eosinophils; glucocorticoids;

D O I：

10.1016/j.cellimm.2003.10.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Eotaxin-1/CCL11, eotaxin-2/CCL24, and eotaxin-3/CCL26 bind specifically and exclusively to CC chemokine receptor (CCR) 3, which is a potential therapeutic target in treating the peribronchial eosinophilia associated with allergic airway diseases. Bronchial epithelial cells represent an important source of chemokines, and thus we investigated in vitro and in vivo expression of eotaxin-2 and eotaxin-3 in bronchial epithelial cells in comparison with that of eotaxin-1. Immunohistochemistry showed increased expression of both eotaxin-2 and cotaxin-3 in addition to eotaxin-1 in asthmatics. Considerable amounts of eotaxins were secreted by bronchial epithelial lineage. As with eotaxin-1 production, generation of eotaxin-2 and eotaxin-3 by bronchial epithelial cells was up-regulated by IL-4 and IL-13, and attenuated by IFN-gamma and glucocorticoids. In addition to eotaxin-1 expression, but also eotaxin-2 and eotaxin-3 expression in the bronchial epithelium should be taken into consideration when developing the therapeutic strategies to treat eosinophilic airway diseases. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：91 / 100

页数：10

共 37 条

[1] Regulation of human eotaxin-3/CCL26 expression: Modulation by cytokines and glucocorticoids [J].