Sustained release of water-soluble drug from directly compressed alginate tablets

被引：51

作者：

Holte, O

Onsoyen, E

Myrvold, R

Karlsen, J

机构：

[1] Univ Oslo, Sch Pharm, Dept Pharmaceut, Fac Math & Nat Sci, N-0316 Oslo, Norway

[2] FMC BioPolymer, Drammen, Norway

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2003年 / 20卷 / 4-5期

关键词：

alginate; tablets; sustained release; acetyl salicylic acid;

D O I：

10.1016/j.ejps.2003.09.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The release of acetyl salicylic acid from directly compressed alginate tablets was investigated. The effect of the amount and type of alginate on the drug release rate was evaluated in different formulations. Four different grades of alginate were used. The in vitro release studies were carried out using the apparatus II (paddle) equipment as described in the USP 23/NF dissolution monograph. Dissolution medium was 0.1 M HCl for 2 h followed by phosphate buffer pH 6.8; both at 37degreesC. Sustained drug release up to 16 h was achieved using sodium alginate in combination with dibasic calcium phosphate. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：403 / 407

页数：5

共 29 条

[1] Excipient-excipient interaction in the design of sustained-release theophylline tablets: In vitro and in vivo evaluation [J].