Genome mining for novel natural product discovery

被引:166
作者
Challis, Gregory L. [1 ]
机构
[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England
基金
英国生物技术与生命科学研究理事会;
关键词
D O I
10.1021/jm700948z
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:2618 / 2628
页数:11
相关论文
共 79 条
[1]   Genomic analysis of the terpenoid synthase (AtTPS) gene family of Arabidopsis thaliana [J].
Aubourg, S ;
Lecharny, A ;
Bohlmann, J .
MOLECULAR GENETICS AND GENOMICS, 2002, 267 (06) :730-745
[2]   Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates [J].
Austin, MB ;
Izumikawa, M ;
Bowman, ME ;
Udwary, DW ;
Ferrer, JL ;
Moore, BS ;
Noel, JP .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (43) :45162-45174
[3]   Terrequinone A biosynthesis through L-tryptophan oxidation, dimerization and bisprenylation [J].
Balibar, Carl J. ;
Howard-Jones, Annaleise R. ;
Walsh, Christopher T. .
NATURE CHEMICAL BIOLOGY, 2007, 3 (09) :584-592
[4]   Isolation and identification of three new 5-alkenyl-3,3(2H)-furanones from two Streptomyces species using a genomic screening approach [J].
Banskota, AH ;
McAlpine, JB ;
Sorensen, D ;
Aouidate, M ;
Piraee, M ;
Alarco, AM ;
Omura, S ;
Shiomi, K ;
Farnet, CM ;
Zazopoulos, E .
JOURNAL OF ANTIBIOTICS, 2006, 59 (03) :168-176
[5]   Genomic analyses lead to novel secondary metabolites [J].
Banskota, Arjun H. ;
McAlpine, James B. ;
Sorensen, Dan ;
Ibrahim, Ashraf ;
Aouidate, Mustapha ;
Piraee, Mahmood ;
Alarco, Anne-Marie ;
Farnet, Chris M. ;
Zazopoulos, Emmanuel .
JOURNAL OF ANTIBIOTICS, 2006, 59 (09) :533-542
[6]   Identification of a cluster of genes that directs desferrioxamine biosynthesis in Streptomyces coelicolor M145 [J].
Barona-Gómez, F ;
Wong, U ;
Giannakopulos, AE ;
Derrick, PJ ;
Challis, GL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (50) :16282-16283
[7]   Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877 [J].
Barona-Gomez, Francisco ;
Lautru, Sylvie ;
Francou, Francois-Xavier ;
Leblond, Pierre ;
Pernodet, Jean-Luc ;
Challis, Gregory L. .
MICROBIOLOGY-SGM, 2006, 152 :3355-3366
[8]   Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) [J].
Bentley, SD ;
Chater, KF ;
Cerdeño-Tárraga, AM ;
Challis, GL ;
Thomson, NR ;
James, KD ;
Harris, DE ;
Quail, MA ;
Kieser, H ;
Harper, D ;
Bateman, A ;
Brown, S ;
Chandra, G ;
Chen, CW ;
Collins, M ;
Cronin, A ;
Fraser, A ;
Goble, A ;
Hidalgo, J ;
Hornsby, T ;
Howarth, S ;
Huang, CH ;
Kieser, T ;
Larke, L ;
Murphy, L ;
Oliver, K ;
O'Neil, S ;
Rabbinowitsch, E ;
Rajandream, MA ;
Rutherford, K ;
Rutter, S ;
Seeger, K ;
Saunders, D ;
Sharp, S ;
Squares, R ;
Squares, S ;
Taylor, K ;
Warren, T ;
Wietzorrek, A ;
Woodward, J ;
Barrell, BG ;
Parkhill, J ;
Hopwood, DA .
NATURE, 2002, 417 (6885) :141-147
[9]   Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans [J].
Bergmann, Sebastian ;
Schuemann, Julia ;
Scherlach, Kirstin ;
Lange, Corinna ;
Brakhage, Axel A. ;
Hertweck, Christian .
NATURE CHEMICAL BIOLOGY, 2007, 3 (04) :213-217
[10]   A new modular polyketide synthase in the erythromycin producer Saccharopolyspora erythraea [J].
Boakes, S ;
Oliynyk, M ;
Cortés, J ;
Böhm, I ;
Rudd, BAM ;
Revill, WP ;
Staunton, J ;
Leadlay, PF .
JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY, 2004, 8 (02) :73-80