Multicenter evaluation of an interdisciplinary 52-week weight loss program for obesity with regard to body weight, comorbidities and quality of life-a prospective study

被引：113

作者：

Bischoff, S. C. ^{[1
]}

Damms-Machado, A. ^{[1
]}

Betz, C. ^{[1
]}

Herpertz, S. ^{[2
]}

Legenbauer, T. ^{[2
]}

Loew, T. ^{[3
]}

Wechsler, J. G. ^{[4
]}

Bischoff, G. ^{[4
]}

Austel, A. ^{[5
]}

Ellrott, T. ^{[5
]}

机构：

[1] Univ Hohenheim, Dept Med Nutr, D-70593 Stuttgart, Germany

[2] Ruhr Univ Bochum, Westfal Klin, Dept Psychosomat Med & Psychotherapy, Dortmund, Germany

[3] Univ Hosp, Dept Psychosomat Med, Regensburg, Germany

[4] Hosp Barmherzige Bruder, Dept Med, Munich, Germany

[5] Univ Gottingen, Sch Med, Inst Nutr & Psychol, Gottingen, Germany

来源：

INTERNATIONAL JOURNAL OF OBESITY | 2012年 / 36卷 / 04期

关键词：

low calorie diet; metabolic syndrome; weight loss; blood pressure; quality of life; BLOOD-PRESSURE; RISK-FACTORS; OVERWEIGHT; EPIDEMIOLOGY; PROGRESSION; PREVALENCE; DISEASE; STYLE;

D O I：

10.1038/ijo.2011.107

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: To determine the effectiveness of a structured multidisciplinary non-surgical obesity therapy program on the basis of a temporary low-calorie-diet for 12 weeks, and additional intervention modules to enhance nutritional education, to increase physical activity and to modify eating behavior. Design: Prospective multicenter observational study in obese individuals undergoing a medically supervised outpatient-based 52-week treatment in 37 centers in Germany. Subjects: A total of 8296 participants with a body mass index (BMI) of 430 kg m(-2) included within 8.5 years. Measurements: Main outcome measures were body weight loss, waist circumference (WC), blood pressure, quality of life and adverse events. Results: In females, initial body weight was reduced after the 1-year-intervention by 19.6 kg (95% confidence intervals 19.2-19.9 kg) and in males by 26.0 kg (25.2-26.8) according to per protocol analysis of 4850 individuals. Intention-to-treat (ITT) analysis revealed a weight reduction of 15.2 kg (14.9-15.6) in females and 19.4 kg (18.7-20.1) in males. Overall, the intervention resulted in mean reduction in WC of 11 cm; it reduced the prevalence of the metabolic syndrome by 50% and the frequency of hypertension from 47 to 29% of all participants (ITT, all P<0.001). The beneficial effects could be documented for up to 3 years and comprised significant improvement of health-related quality of life. The incidence of adverse effects was low; the only event repeatedly observed and possibly related to either the intervention or the underlying disease was biliary disorders. Conclusion: The present non-surgical intervention program is a highly effective treatment of obesity grades I-III and obesity-related diseases, and therefore, could be a valuable basis for future weight maintenance strategies required for sustained success. International Journal of Obesity (2012) 36, 614-624; doi: 10.1038/ijo.2011.107; published online 14 June 2011

引用

页码：614 / 624

页数：11

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