Ozonolysis of phospholipid double bonds during electrospray ionization: A new tool for structure determination

被引：127

作者：

Thomas, MC

Mitchell, TW

Blanksby, SJ ^{[1
]}

机构：

[1] Univ Wollongong, Dept Chem, Wollongong, NSW 2522, Australia

[2] Univ Wollongong, Dept Biomed Sci, Wollongong, NSW 2522, Australia

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 01期

关键词：

D O I：

10.1021/ja056797h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ozonolysis of double bonds is observed during the negative ion electrospray ionization of unsaturated phospholipids under conditions that produce a corona discharge. Ionic products of the ozonolysis are detected and characterized by mass spectrometry, and the mass-to-charge ratio of these species can be used to unambiguously assign the double bond position within the unsaturated fatty acid radyls. The reaction products are consistent with the gas-phase ozonolysis of desolvated phospholipid ions in an atmosphere rich in volatilized solvent. Reactions may be carried out in a conventional electrospray ionization mass spectrometer and provide a new method for the structural characterization of phospholipids. Copyright © 2006 American Chemical Society.

引用

页码：58 / 59

页数：2

共 26 条

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2-E

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