Synthesis of the isomers of (1R)-3-(phenylthio)tropane-2-carboxylic acid methyl ester. A new class of ligands for the dopamine transporter

被引：6

作者：

Thiruvazhi, M

Abraham, P

Kuhar, MJ

Carroll, FI

机构：

[1] RES TRIANGLE INST,RES TRIANGLE PK,NC 27709

[2] NIDA,ADDICT RES CTR,BALTIMORE,MD 21224

来源：

CHEMICAL COMMUNICATIONS | 1997年 / 06期

关键词：

D O I：

10.1039/a608238f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The syntheses of all four isomers of (1R)-3-(phenylthio)tropane-2-carboxylic acid methyl ester are described; the 2 beta,3 beta-isomer shows high affinity for the cocaine binding site on the dopamine transporter.

引用

页码：555 / 556

页数：2

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