Structural brain alterations in subjects at high-risk of psychosis:: A voxel-based morphometric study

被引：115

作者：

Meisenzahl, E. M. ^{[1
]}

Koutsouleris, N. ^{[1
]}

Gaser, C. ^{[3
]}

Bottlender, R. ^{[1
]}

Schmitt, G. J. E. ^{[1
]}

McGuire, P. ^{[4
]}

Decker, P. ^{[1
]}

Burgermeister, B. ^{[1
]}

Born, C. ^{[2
]}

Reiser, Maximilian ^{[2
]}

Moeller, H. -J ^{[1
]}

机构：

[1] Univ Munich, Dept Psychiat & Psychotherapy, D-80336 Munich, Germany

[2] Univ Munich, Dept Radiol, D-80336 Munich, Germany

[3] Univ Jena, Dept Psychiat, Jena, Germany

[4] Kings Coll London, Inst Psychiat, Dept Psychol Med, London, England

来源：

SCHIZOPHRENIA RESEARCH | 2008年 / 102卷 / 1-3期

关键词：

prodromal psychosis; imaging; voxel-based morphometry; schizophrenia;

D O I：

10.1016/j.schres.2008.02.023

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Forty Untreated high-risk (HR) individuals for psychosis and 75 healthy control subjects (HC) matched for age, gender, handedness and educational level were investigated by structural MRI. HR subjects were recruited at the Early Detection and Intervention Centre for Mental Crises (FETZ) of the Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Germany. Measurements of gray matter volumes were performed by voxel-based morphometry using SPM5. The sample of HR subjects showed GM volume reductions in frontal, lateral temporal and medial temporal regions compared to the healthy control group. These regions are compatible with structural findings in the clinically apparent disease of schizophrenia. (c) 2008 Elsevier B.V All rights reserved.

引用

页码：150 / 162

页数：13

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