Hematopoiesis: An evolving paradigm for stem cell biology

被引：1745

作者：

Orkin, Stuart H. ^{[1
,2
,3
]}

Zon, Leonard I. ^{[1
,2
,3
]}

机构：

[1] Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Stem Cell Inst, Boston, MA 02115 USA

[3] Howard Hughes Med Inst, Boston, MA 02115 USA

来源：

CELL | 2008年 / 132卷 / 04期

关键词：

D O I：

10.1016/j.cell.2008.01.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Establishment and maintenance of the blood system relies on self-renewing hematopoietic stem cells (HSCs) that normally reside in small numbers in the bone marrow niche of adult mammals. This Review describes the developmental origins of HSCs and the molecular mechanisms that regulate lineage-specific differentiation. Studies of hematopoiesis provide critical insights of general relevance to other areas of stem cell biology including the role of cellular interactions in development and tissue homeostasis, lineage programming and reprogramming by transcription factors, and stage- and age-specific differences in cellular phenotypes.

引用

页码：631 / 644

页数：14

共 113 条

[1] Alden S., 2007, NAT REP STEM CELLS, DOI [DOI 10.1038/STEMCELLS.2007.42, 10.1038/stemcells.2007.22, DOI 10.1038/STEMCELLS.2007.22]
[2] Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages
Arinobu, Yojiro
Mizuno, Shin-ichi
Chong, Yong
Shigematsu, Hirokazu
Lino, Tadafumi
Iwasaki, Hiromi
Graf, Thomas
Mayfield, Robin
Chan, Susan
Kastner, Philippe
Akashi, Koichi
[J]. CELL STEM CELL, 2007, 1 (04) : 416 - 427
[3] Characterization of purified intraembryonic hematopoietic stem cells as a tool to define their site of origin
Bertrand, JY
Giroux, S
Golub, R
Klaine, M
Jalil, A
Boucontet, L
Godin, I
Cumano, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (01) : 134 - 139
[4] Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties
Bowie, Michelle B.
Kent, David G.
Dykstra, Brad
McKnight, Kristen D.
McCaffrey, Lindsay
Hoodless, Pamela A.
Eaves, Connie J.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (14) : 5878 - 5882
[5] Distinct domains of erythroid Kruppel-like factor modulate chromatin remodeling and transactivation at the endogenous β-globin gene promoter
Brown, RC
Pattison, S
van Ree, J
Coghill, E
Perkins, A
Jane, SM
Cunningham, JM
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (01) : 161 - 170
[6] A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in β-globin expression and erythroid development
Bultman, SJ
Gebuhr, TC
Magnuson, T
[J]. GENES & DEVELOPMENT, 2005, 19 (23) : 2849 - 2861
[7] Hematopoietic stem cell fate is established by the Notch-Runx pathway
Burns, CE
Traver, D
Mayhall, E
Shepard, JL
Zon, LI
[J]. GENES & DEVELOPMENT, 2005, 19 (19) : 2331 - 2342
[8] Osteoblastic cells regulate the haematopoietic stem cell niche
Calvi, LM
Adams, GB
Weibrecht, KW
Weber, JM
Olson, DP
Knight, MC
Martin, RP
Schipani, E
Divieti, P
Bringhurst, FR
Milner, LA
Kronenberg, HM
Scadden, DT
[J]. NATURE, 2003, 425 (6960) : 841 - 846
[9] MicroRNAs modulate hematopoietic lineage differentiation
Chen, CZ
Li, L
Lodish, HF
Bartel, DP
[J]. SCIENCE, 2004, 303 (5654) : 83 - 86
[10] Developmental control of blood cell migration by the Drosophila VEGF pathway
Cho, NK
Keyes, L
Johnson, E
Heller, J
Ryner, L
Karim, F
Krasnow, MA
[J]. CELL, 2002, 108 (06) : 865 - 876

← 1 2 3 4 5 6 7 8 9 10 →