Chemical immunosuppression in islet transplantation - Friend or foe?

被引：21

作者：

Chatenoud, Lucienne ^{[1
]}

机构：

[1] Univ Paris 05, Paris, France

[2] INSERM, Unite 580, Paris, France

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2008年 / 358卷 / 11期

关键词：

D O I：

10.1056/NEJMcibr0708067

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Experiments using a mouse model of type 1 diabetes indicate that immunosuppressants used in islet transplantation may suppress beta-cell proliferation. Copyright © 2008 Massachusetts Medical Society. All rights reserved.

引用

页码：1192 / 1193

页数：2

共 5 条

[1] ANTI-CD3 ANTIBODY INDUCES LONG-TERM REMISSION OF OVERT AUTOIMMUNITY IN NONOBESE DIABETIC MICE [J].

CHATENOUD, L ;

THERVET, E ;

PRIMO, J ;

BACH, JF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (01) :123-127

[2] Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration? [J].

Meier, JJ ;

Bhushan, A ;

Butler, AE ;

Rizza, RA ;

Butler, PC .

DIABETOLOGIA, 2005, 48 (11) :2221-2228

[3] Recovery from diabetes in mice by β cell regeneration [J].

Nir, Tomer ;

Melton, Douglas A. ;

Dor, Yuval .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (09) :2553-2561

[4] Exendin-4 improves reversal of diabetes in NOD mice treated with Anti-CD3 monoclonal antibody by enhancing recovery of β-cells [J].

Sherry, Nicole A. ;

Chen, Wei ;

Kushner, Jake A. ;

Glandt, Mariela ;

Tang, Qizhi ;

Tsai, Sue ;

Santamaria, Pere ;

Bluestone, Jeffrey A. ;

Brillantes, Anne-Marie B. ;

Herold, Kevan C. .

ENDOCRINOLOGY, 2007, 148 (11) :5136-5144

[5] Increased β-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse [J].

Sreenan, S ;

Pick, AJ ;

Levisetti, M ;

Baldwin, AC ;

Pugh, M ;

Polonsky, KS .

DIABETES, 1999, 48 (05) :989-996

← 1 →