β-PVDF based electrospun nanofibers - A promising material for developing cardiac patches

被引:41
作者
Arumugam, Ratnakar [1 ,2 ]
Srinadhu, Endu Sekhar [3 ]
Subramanian, Balanehru [4 ,5 ]
Nallani, Satyanarayana [1 ]
机构
[1] Pondicherry Univ, Dept Phys, Pondicherry, India
[2] Pondicherry Univ, Ctr Nanosci & Technol, Pondicherry, India
[3] Clemson Univ, Dept Phys & Astron, Clemson, SC 29631 USA
[4] Mahathma Gandhi Med Coll & Res Inst, Cent Interdisciplinary Res Facil, Pondicherry, India
[5] Mahathma Gandhi Med Coll & Res Inst, Ctr Anim Res Traning & Serv, Pondicherry, India
关键词
Necrosis; Heart muscles; beta-PVDF; Nanocomposite; Cardiac patches; STEM-CELL THERAPY; CARDIOMYOCYTE PROLIFERATION; REGENERATION;
D O I
10.1016/j.mehy.2018.10.005
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
100103 [病原生物学]; 100218 [急诊医学];
摘要
Necrosis in heart muscles can permanently hinder the natural healthy rhythm of heart pumping mechanism. The damaged muscular tissues are replaced by scar tissues and burdens the healthy muscles resulting in further attenuated functioning of heart. Since, human heart muscles cannot regenerate naturally or it has been thought so, pharmacological procedures such as using a heart assist device are followed to restore the lost function of heart. Stem cell engineering and cardiac patches offers promising prospects with their cutting edge research reports. Cardiac patches offers a viable solution as they can also function as an implant to assist in offering the mechanical support the damaged muscles were capable of. Designing cardiac patches to suit multiple functions is not only challenging but also perilous due to the target organ with which it will be interfaced. Sensor based, electrically active, miniaturized circuitry etc., poses a huge threat to the individual in whom the device/patch is implanted. In this paper, we propose a hypothesis on choosing beta-PVDF based nanocomposites as the inimitable material for designing implantable cardiac patches. beta-PVDF based nanocomposite materials is expected to exhibit piezoelectric effect and contribute to the adherence, proliferation and maturation of stem cells. Physicochemical characterizations followed by in vitro cell line studies were performed in ought to confirm the same. The results revealed that the beta-PVDF based nanocomposite material was mechanically stable and supportive in cardiomyocyte adherence and differentiation when compared to standard non piezoelectric scaffolds (control). Hence, an implantable beta-PVDF based novel electrospun nanocomposite scaffold is hypothesized to be the hour of need in conjugation with stem cell engineering for repairing damaged heart muscles.
引用
收藏
页码:31 / 34
页数:4
相关论文
共 29 条
[1]
Antoniou G, 2018, HOLOCAUST IN GREECE, P1
[2]
Electrospun poly(vinylidene fluoride-trifluoroethylene)/zinc oxide nanocomposite tissue engineering scaffolds with enhanced cell adhesion and blood vessel formation [J].
Augustine, Robin ;
Dan, Pan ;
Sosnik, Alejandro ;
Kalarikkal, Nandakumar ;
Tran, Nguyen ;
Vincent, Brice ;
Thomas, Sabu ;
Menu, Patrick ;
Rouxel, Didier .
NANO RESEARCH, 2017, 10 (10) :3358-3376
[3]
Bruneau Benoit G., 2013, COLD SPRING HARB PER, V5
[4]
Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses [J].
Clerk, Angela ;
Cullingford, Timothy E. ;
Fuller, Stephen J. ;
Giraldo, Alejandro ;
Markou, Thomais ;
Pikkarainen, Sampsa ;
Sugden, Peter H. .
JOURNAL OF CELLULAR PHYSIOLOGY, 2007, 212 (02) :311-322
[5]
Feiner R, 2016, NAT MATER, V15, P679, DOI [10.1038/NMAT4590, 10.1038/nmat4590]
[6]
Modular assembly of thick multifunctional cardiac patches [J].
Fleischer, Sharon ;
Shapira, Assaf ;
Feiner, Ron ;
Dvir, Tal .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (08) :1898-1903
[7]
Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering [J].
Ghasemi-Mobarakeh, Laleh ;
Prabhakaran, Molamma P. ;
Morshed, Mohammad ;
Nasr-Esfahani, Mohammad Hossein ;
Baharvand, Hossein ;
Kiani, Sahar ;
Al-Deyab, SalemS ;
Ramakrishna, Seeram .
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2011, 5 (04) :E17-E35
[8]
Cardiac stem cell therapy for cardiac repair [J].
Hong K.U. ;
Bolli R. .
Current Treatment Options in Cardiovascular Medicine, 2014, 16 (7)
[9]
Jaicy Jacob, 2018, INFLAMMAT REGENERAT, V38, P11
[10]
PVDF piezoelectric neural conduit incorporated pre-differentiated adipose derived stem cells may accelerate the repair of peripheral nerve injury [J].
Li Ming ;
Zhang Peixun ;
Zhang Dianying .
MEDICAL HYPOTHESES, 2018, 114 :55-57