Cholecystokinin and thermoregulation -: a minireview

被引：18

作者：

Szelényi, Z ^{[1
]}

机构：

[1] Univ Pecs, Fac Med, Dept Pathophysiol, H-7624 Pecs, Hungary

来源：

PEPTIDES | 2001年 / 22卷 / 08期

基金：

匈牙利科学研究基金会;

关键词：

cholecystokinin; thermoregulation; hypothermia; hyperthermia; fever;

D O I：

10.1016/S0196-9781(01)00448-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thermoregulatory effects of cholecystokinin (CCK) peptides are reviewed with special emphasis on two types of responses, that is hypothermia or hyperthermia. In rodents exposed to cold a dose-dependent hypothermia has been observed on peripheral injection of CCK probably acting on CCKA receptors. Central microinjection of CCK in rats induced a thermogenic response that could be attenuated by CCKB receptor antagonists, but some authors observed a hypothermia. It is suggested that neuronal CCK map have a specific role in the development of hyperthermia, and endogenous CCK-ergic mechanisms could contribute to the mediation of fever. Possible connections between thermoregulatory and other autonomic functional changes induced by CCK are discussed. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：1245 / 1250

页数：6

共 51 条

[1] IN MAN THE MU-OPIATE AGONIST LOPERAMIDE SPECIFICALLY INHIBITS ACTH-SECRETION INDUCED BY THE CHOLECYSTOKININ-LIKE PEPTIDE CERULETIDE [J].

AUERNHAMMER, CJ ;

RIEPL, RL ;

SCHOPOHL, J ;

LEHNERT, P ;

MULLER, OA ;

STALLA, GK .

NEUROENDOCRINOLOGY, 1994, 60 (01) :16-22

[2] Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice [J].

Barrachina, MD ;

Martinez, V ;

Wang, LX ;

Wei, JY ;

Tache, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (19) :10455-10460

[3] DISTRIBUTION OF CHOLECYSTOKININ (CCK) IN THE HYPOTHALAMUS AND LIMBIC SYSTEM OF THE RAT [J].

BEINFELD, MC ;

PALKOVITS, M .

NEUROPEPTIDES, 1981, 2 (02) :123-129

[4] A cholecystokinin-mediated pathway to the paraventricular thalamus is recruited in chronically stressed rats and regulates hypothalamic-pituitary-adrenal function [J].

Bhatnagar, S ;

Viau, V ;

Chu, A ;

Soriano, L ;

Meijer, OC ;

Dallman, MF .

JOURNAL OF NEUROSCIENCE, 2000, 20 (14) :5564-5573

[5] Effects of paraventricular nucleus injection of CCK-8 on plasma CCK-8 levels in rats [J].

Blevins, JE ;

Hamel, FG ;

Fairbairn, E ;

Stanley, BG ;

Reidelberger, RD .

BRAIN RESEARCH, 2000, 860 (1-2) :11-20

[6] Cholecystokinin receptors do not mediate the suppression of food-motivated behavior by lipopolysaccharide and interleukin-1 beta in mice [J].

Bret-Dibat, JL ;

Dantzer, R .

PHYSIOLOGY & BEHAVIOR, 2000, 69 (03) :325-331

[7] Selective activation of CCK-B receptors does not induce sleep and does not affect EEG slow-wave activity and brain temperature in rats [J].

Chang, HY ;

Kapas, L .

PHYSIOLOGY & BEHAVIOR, 1997, 62 (01) :175-179

[8] THE INDUCTION AND SUPPRESSION OF C-FOS EXPRESSION IN THE RAT-BRAIN BY CHOLECYSTOKININ AND ITS ANTAGONIST L364,718 [J].

CHEN, DY ;

DEUTSCH, JA ;

GONZALEZ, MF ;

GU, Y .

NEUROSCIENCE LETTERS, 1993, 149 (01) :91-94

[9] CHANGES IN BODY-TEMPERATURE AFTER ADMINISTRATION OF AMINO-ACIDS, PEPTIDES, DOPAMINE, NEUROLEPTICS AND RELATED AGENTS .2. [J].

CLARK, WG ;

LIPTON, JM .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1985, 9 (02) :299-371

[10]

CROSSMELLOR SK, 1999, AM J PHYSL, V277

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