Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?

被引：643

作者：

DeBerardinis, Ralph J. ^{[1
,2
]}

Thompson, Craig B. ^{[3
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Pediat, Childrens Res Inst, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

[3] Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA

来源：

CELL | 2012年 / 148卷 / 06期

关键词：

FUMARATE-HYDRATASE; IDH2; MUTATIONS; ALPHA-KETOGLUTARATE; RENAL-CANCER; DEHYDROGENASE; GROWTH; GENE; GLUTAMINE; PATHWAY; PROTEIN;

D O I：

10.1016/j.cell.2012.02.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An understanding of metabolic pathways based solely on biochemistry textbooks would underestimate the pervasive role of metabolism in essentially every aspect of biology. It is evident from recent work that many human diseases involve abnormal metabolic states-often genetically programmed-that perturb normal physiology and lead to severe tissue dysfunction. Understanding these metabolic outliers is now a crucial frontier in disease-oriented research. This Review discusses the broad impact of metabolism in cellular function and how modern concepts of metabolism can inform our understanding of common diseases like cancer and also considers the prospects of developing new metabolic approaches to disease treatment.

引用

页码：1132 / 1144

页数：13

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