Why sepsis trials fail

被引:168
作者
Bone, RC
机构
来源
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 1996年 / 276卷 / 07期
关键词
D O I
10.1001/jama.276.7.565
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:565 / 566
页数:2
相关论文
共 29 条
[1]   EFFICACY AND SAFETY OF MONOCLONAL-ANTIBODY TO HUMAN TUMOR-NECROSIS-FACTOR-ALPHA IN PATIENTS WITH SEPSIS SYNDROME - A RANDOMIZED, CONTROLLED, DOUBLE-BLIND, MULTICENTER CLINICAL-TRIAL [J].
ABRAHAM, E ;
WUNDERINK, R ;
SILVERMAN, H ;
PERL, TM ;
NASRAWAY, S ;
LEVY, H ;
BONE, R ;
WENZEL, RP ;
BALK, R ;
ALLRED, R ;
PENNINGTON, JE ;
WHERRY, JC .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 273 (12) :934-941
[2]   A 2ND LARGE CONTROLLED CLINICAL-STUDY OF E5, A MONOCLONAL-ANTIBODY TO ENDOTOXIN - RESULTS OF A PROSPECTIVE, MULTICENTER, RANDOMIZED, CONTROLLED TRIAL [J].
BONE, RC ;
BALK, RA ;
FEIN, AM ;
PERL, TM ;
WENZEL, RP ;
REINES, HD ;
QUENZER, RW ;
IBERTI, TJ ;
MACINTYRE, N ;
SCHEIN, RMH ;
TRENHOLME, G ;
NIEDERMAN, M ;
CHALFIN, D ;
ABALOS, A ;
OROPELLO, J ;
EMPSON, P ;
CAMINITII, S ;
GREENMAN, R ;
BOOTH, F ;
PLOUFFE, J ;
RUSSELL, J ;
GIANAKOPOULOS, G ;
IANNINI, P ;
HINDES, R ;
COBLENS, K ;
KOHLER, R ;
MARTIN, M ;
BERNARD, G ;
EDWARDS, J ;
CRISLIP, M ;
FILLER, S ;
NASRAWAY, SA ;
SIGEL, PK ;
SOTTILE, FD ;
MARTIN, DH ;
DEBOISBLANC, BP ;
CHANDRASEKAR, PH ;
BROUGHTON, WA ;
MIDDLETON, RM ;
SEIBERT, AF ;
EMMANUEL, G ;
LIE, TH ;
ANDERSON, CLV ;
PANKEY, GA ;
ANDERSON, P ;
OLSEN, K ;
SANPEDRO, GS ;
GRAHAM, D ;
GROSSMAN, J ;
WELS, PB .
CRITICAL CARE MEDICINE, 1995, 23 (06) :994-1006
[3]   A CONTROLLED CLINICAL-TRIAL OF HIGH-DOSE METHYLPREDNISOLONE IN THE TREATMENT OF SEVERE SEPSIS AND SEPTIC SHOCK [J].
BONE, RC ;
FISHER, CJ ;
CLEMMER, TP ;
SLOTMAN, GJ ;
METZ, CA ;
BALK, RA .
NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (11) :653-658
[5]  
BRUNET F, 1995, AM J RESP CRIT CARE, V151, P1269
[6]  
CARLET, 1995, CURR OPIN CRIT CARE, V1, P349
[7]   PLASMA CYTOKINE AND ENDOTOXIN LEVELS CORRELATE WITH SURVIVAL IN PATIENTS WITH THE SEPSIS SYNDROME [J].
CASEY, LC ;
BALK, RA ;
BONE, RC .
ANNALS OF INTERNAL MEDICINE, 1993, 119 (08) :771-778
[8]   NEUTROPHIL FUNCTION IN SURGICAL PATIENTS - 2 INHIBITORS OF GRANULOCYTE CHEMOTAXIS ASSOCIATED WITH SEPSIS [J].
CHRISTOU, NV ;
MEAKINS, JL .
JOURNAL OF SURGICAL RESEARCH, 1979, 26 (04) :355-364
[9]   PLATELET-ACTIVATING-FACTOR RECEPTOR ANTAGONIST BN-52021 IN THE TREATMENT OF SEVERE SEPSIS - A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER CLINICAL-TRIAL [J].
DHAINAUT, JFA ;
TENAILLON, A ;
LETULZO, Y ;
SCHLEMMER, B ;
SOLET, JP ;
WOLFF, M ;
HOLZAPFEL, L ;
ZENI, F ;
DREYFUSS, D ;
MIRA, JP ;
DEVATHAIRE, F ;
GUINOT, P .
CRITICAL CARE MEDICINE, 1994, 22 (11) :1720-1728
[10]  
FAIST E, 1992, SURGERY, V112, P562