Vascular endothelial growth factor counteracts NMDA-induced cell death of adult cholinergic neurons in rat basal nucleus of Meynert

被引：17

作者：

Moser, KV ^{[1
]}

Humpel, C ^{[1
]}

机构：

[1] Innsbruck Med Univ, Univ Clin Psychiat, Lab Psychiat, A-6020 Innsbruck, Austria

来源：

BRAIN RESEARCH BULLETIN | 2005年 / 65卷 / 02期

关键词：

VEGF; cholinergic neurons; NMDA; basal nucleus of Meynert; neuroprotection; angiogenesis; vascular structures; capillaries; RECA-1;

D O I：

10.1016/j.brainresbull.2004.12.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis in the brain and has recently been shown to possess neuroprotective activity. The aim of the present study was to observe if VEGF can counteract the excitotoxic N-methyl-D-aspartate (NMDA)induced cell death of cholinergic neurons of the basal nucleus of Meynert in vivo in adult rats. Immunohistochemistry was used to detect vascular structures (RECA-1 or laminin staining) and cholinergic neurons (choline-acetyltransferase). To compare the in vivo VEGF effects also in vitro, VEGF was applied to axotomized cholinergic neurons in organotypic brain slices with or without NMDA. Our data provide evidence that VEGF counteracted cell death in vivo in adult rats but did not protect cholinergic neurons in developing brain slices. Nerve growth factor protected cholinergic neurons in vivo as well as in vitro. In conclusion, VEGF exhibits neuroprotective activity on adult cholinergic neurons of the basal nucleus of Meynert. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：125 / 131

页数：7

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