Epidemiology of comorbid coronary artery disease and depression

被引:438
作者
Rudisch, B [1 ]
Nemeroff, CB [1 ]
机构
[1] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
关键词
depression; coronary artery disease; epidemiology; risk factor; comorbidity;
D O I
10.1016/S0006-3223(03)00587-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This article reviews the epidemiology of comorbid coronary artery disease and unipolar depression. Both major depression and subsyndromal depressive symptoms will be considered; unless otherwise specified, the term depression will be used to designate all depressive states, including major depressive disorder, minor depression, dysthymia, and other subsyndromal forms of depression. While 17% to 27% of patients with coronary artery disease have major depression, a significantly larger percentage has subsyndromal symptoms of depression. Patients with coronary artery disease and depression have a twofold to threefold increased risk of future cardiac events compared to patients without depression, independent of baseline cardiac dysfunction. The relative risk for the development of coronary artery disease conferred by depression in patients initially free of clinical cardiac disease is approximately 1.5, independent of other known risk factors for coronary disease. In the discussion, special attention will be paid to the interactions of both gender and age with depression and coronary artery disease risk. Scrutiny of the role of confounding risk factors is presented, such as global burden of comorbid medical illness and modification of traditional risk factors, which may, in part, mediate the effect of depression on coronary artery disease. (C) 2003 Society of Biological Psychiatry.
引用
收藏
页码:227 / 240
页数:14
相关论文
共 115 条
[1]   Gender and psychosomatic aspects of ischemic heart disease [J].
Abbey, SE ;
Stewart, DE .
JOURNAL OF PSYCHOSOMATIC RESEARCH, 2000, 48 (4-5) :417-423
[2]   BIOBEHAVIORAL VARIABLES AND MORTALITY OR CARDIAC-ARREST IN THE CARDIAC-ARRHYTHMIA PILOT-STUDY (CAPS) [J].
AHERN, DK ;
GORKIN, L ;
ANDERSON, JL ;
TIERNEY, C ;
HALLSTROM, A ;
EWART, C ;
CAPONE, RJ ;
SCHRON, E ;
KORNFELD, D ;
HERD, JA ;
RICHARDSON, DW ;
FOLLICK, MJ .
AMERICAN JOURNAL OF CARDIOLOGY, 1990, 66 (01) :59-62
[3]  
Alexopoulos GS, 1997, ARCH GEN PSYCHIAT, V54, P915
[4]   MEDICAL AND ECONOMIC COSTS OF PSYCHOLOGIC DISTRESS IN PATIENTS WITH CORONARY-ARTERY DISEASE [J].
ALLISON, TG ;
WILLIAMS, DE ;
MILLER, TD ;
PATTEN, CA ;
BAILEY, KR ;
SQUIRES, RW ;
GAU, GT .
MAYO CLINIC PROCEEDINGS, 1995, 70 (08) :734-742
[5]   DEPRESSED AFFECT, HOPELESSNESS, AND THE RISK OF ISCHEMIC-HEART-DISEASE IN A COHORT OF UNITED-STATES ADULTS [J].
ANDA, R ;
WILLIAMSON, D ;
JONES, D ;
MACERA, C ;
EAKER, E ;
GLASSMAN, A ;
MARKS, J .
EPIDEMIOLOGY, 1993, 4 (04) :285-293
[6]   DEPRESSION AND THE DYNAMICS OF SMOKING - A NATIONAL PERSPECTIVE [J].
ANDA, RF ;
WILLIAMSON, DF ;
ESCOBEDO, LG ;
MAST, EE ;
GIOVINO, GA ;
REMINGTON, PL .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1990, 264 (12) :1541-1545
[7]   Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical features [J].
Anisman, H ;
Ravindran, AV ;
Griffiths, J ;
Merali, Z .
MOLECULAR PSYCHIATRY, 1999, 4 (02) :182-188
[8]   EXCESS FATIGUE AS A PRECURSOR OF MYOCARDIAL-INFARCTION [J].
APPELS, A ;
MULDER, P .
EUROPEAN HEART JOURNAL, 1988, 9 (07) :758-764
[9]   Vital exhaustion, extent of atherosclerosis, and the clinical course after successful percutaneous transluminal coronary angioplasty [J].
Appels, A ;
Kop, W ;
Bar, F ;
deSwart, H ;
deLeon, CM .
EUROPEAN HEART JOURNAL, 1995, 16 (12) :1880-1885
[10]  
Ariyo AA, 2000, CIRCULATION, V102, P1773