COMPACT: a structural approach to the modelling of cytochromes P450 and their interactions with xenobiotics

被引：30

作者：

Lewis, DFV ^{[1
]}

机构：

[1] Univ Surrey, Sch Biol Sci, Guildford GU2 5XH, Surrey, England

来源：

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY | 2001年 / 76卷 / 03期

关键词：

cytochromes P450; COMPACT (computer - optimized molecular parametric analysis of chemical toxicity; QSAR (quantitative structure - activity relationship);

D O I：

10.1002/jctb.363

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

An overview of the COMPACT method for evaluating potential toxicity mediated by cytochrome P450 enzymes is presented. Particular aspects of P450s are described, together with details of QSARs and homology modelling of mammalian P450s associated with foreign compound metabolism. (C) 2001 Society of Chemical Industry.

引用

页码：237 / 244

页数：8

共 53 条

[1]

BROWN SJ, 1994, ATLA-ALTERN LAB ANIM, V22, P482

[2]

Dearden JC, 1997, ATLA-ALTERN LAB ANIM, V25, P223

[3]

GUENGERICH FP, 1995, CYTOCHROME P450

[4] INDUCTION OF CYTOCHROME P4501 AS AN INDICATOR OF POTENTIAL CHEMICAL CARCINOGENESIS [J].

IOANNIDES, C ;

PARKE, DV .

DRUG METABOLISM REVIEWS, 1993, 25 (04) :485-501

[5]

LAKE BG, 1994, CYTOCHROME P450 META, P271

[6]

Lewis D, 1997, CHILD LIT EDUC, V28, P235, DOI 10.1023/A:1022475205412

[7]

LEWIS D, 1997, CHEM IND, V20, P831

[8]

LEWIS DE, 1994, NEONATAL INTENSIVE C, V7, P24

[9]

Lewis DF., 1996, CYTOCHROMES P450 STR

[10] MOLECULAR MODELING OF ENZYMES AND RECEPTORS INVOLVED IN CARCINOGENESIS - QSARS AND COMPACT-3D [J].

LEWIS, DFV ;

MOEREELS, H ;

LAKE, BG ;

IOANNIDES, C ;

PARKE, DV .

DRUG METABOLISM REVIEWS, 1994, 26 (1-2) :261-285

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