Redox biology: Interface of the exposome with the proteome, epigenome and genome

被引：46

作者：

Go, Young-Mi ^{[1
]}

Jones, Dean P. ^{[1
]}

机构：

[1] Emory Univ, Dept Med, Div Pulm Allergy & Crit Care Med, Whitehead Res Ctr 205, Atlanta, GA 30322 USA

来源：

REDOX BIOLOGY | 2014年 / 2卷

关键词：

Oxidative stress; Redox signaling; Life cycle; Environmental exposures; Personalized medicine; VITAMIN-C-DEFICIENCY; INCREASED OXIDATIVE STRESS; ISCHEMIC BRAIN-INJURY; HUMAN-FETAL TISSUES; GUINEA-PIG BRAIN; ASCORBIC-ACID; SUPEROXIDE-DISMUTASE; LIPID-PEROXIDATION; DIFFERENTIAL EXPRESSION; GLUTATHIONE DEFICIENCY;

D O I：

10.1016/j.redox.2013.12.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The exposome is the cumulative measure of environmental influences and associated biological responses throughout lifespan, including exposures from the environment, diet, behavior and endogenous processes. Much of the direct interaction of an individual's exposome involves redox biology as the body responds to environmental, dietary and behavioral risk factors of disease. The present commentary addresses this critical interface and the need for redox biologists to lead development of concepts and strategies to sequence the exposome. (C) 2014 The Authors. Published by Elsevier B.V.

引用

页码：358 / 367

页数：10

共 60 条

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Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse [J].