Helicobacter pylori antigen-specific T-cell responses at gastric level in chronic gastritis, peptic ulcer, gastric cancer and low-grade mucosa-associated lymphoid tissue (MALT) lymphoma

被引：43

作者：

D'Elios, MM ^{[1
]}

Amedei, A ^{[1
]}

Del Prete, G ^{[1
]}

机构：

[1] Univ Florence, Dept Internal Med, I-50134 Florence, Italy

来源：

MICROBES AND INFECTION | 2003年 / 5卷 / 08期

关键词：

mucosal immunity; Th1-th2; response; cytokines; Helicobacter pvtori; chronic gastritis; peptic ulcer; gastric cancer; gastric lymphoma;

D O I：

10.1016/S1286-4579(03)00114-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Host T-cell response to Helicobacter pylori is important for the clinical outcome of the infection. A Th1-polarized response, preferentially against Ca-A. is associated with peptic ulcer, whereas mixed Th1 and Th0 responses are present in non-ulcer gastritis. A deregulated H. pylori-driven Th0 cell-dependent B-cell activation is found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

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页码：723 / 730

页数：8

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