Remote spatial memory in an amnesic person with extensive bilateral hippocampal lesions

被引:214
作者
Rosenbaum, RS
Priselac, S
Köhler, S
Black, SE
Gao, FQ
Nadel, L
Moscovitch, M
机构
[1] Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada
[2] McGill Univ, Montreal Neurol Inst, Cognit Neurosci Unit, Montreal, PQ H3A 2B4, Canada
[3] Sunnybrook & Womens Coll Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada
[4] Univ Arizona, Dept Psychol & Neural Syst, Memory & Aging Div, Tucson, AZ 85721 USA
[5] Baycrest Ctr Geriatr Care, Rotman Res Inst, Toronto, ON M6A 2E1, Canada
[6] Baycrest Ctr Geriatr Care, Dept Psychol, Toronto, ON M6A 2E1, Canada
基金
英国医学研究理事会;
关键词
D O I
10.1038/79867
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The hippocampus may have a time-limited role in memory, being needed only until information is permanently stored elsewhere, or this region may permanently represent long-term allocentric spatial information or cognitive maps in memory. To test these ideas, we investigated remote spatial memory in K.C., a patient with bilateral hippocampal lesions and amnesia for autobiographical events. In his spatial knowledge, general aspects were preserved, but details were lost, a pattern that resembled his memory loss in other domains. K.C. performed normally on allocentric spatial tests of his neighborhood and the world. He had difficulty, however, in recognizing and identifying non-salient neighborhood landmarks, and in recognizing city locations on world maps. This suggests that the hippocampus is not crucial for maintenance and retrieval of remotely formed spatial representations of major landmarks, routes, distances and directions, but is necessary for specifying location details, regardless of when they were acquired.
引用
收藏
页码:1044 / 1048
页数:5
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