TNM staging of midgut and hindgut (neuro) endocrine tumors:: a consensus proposal including a grading system

被引：724

作者：

Rindi, G.

Kloeppel, G.

Couvelard, A.

Komminoth, P.

Koerner, M.

Lopes, J. M.

McNicol, A-M.

Nilsson, O.

Perren, A.

Scarpa, A.

Scoazec, J-Y.

Wiedenmann, B.

机构：

[1] Univ Parma, Dipartimento Patol & Med Lab, Sez Anat Patol, I-43100 Parma, Italy

[2] Univ Parma, Dept Pathol, I-43100 Parma, Italy

[3] Univ Kiel, Dept Pathol, D-2300 Kiel, Germany

[4] Hop Beaujon, Dept Pathol, Clichy, France

[5] Stadspital Triemli, Dept Pathol, Zurich, Switzerland

[6] Univ Bern, Dept Pathol, CH-3000 Bern, Switzerland

[7] Univ Porto, Dept Pathol, Porto Med Sch, P-4100 Oporto, Portugal

[8] Univ Porto, IPATIMUP, P-4100 Oporto, Portugal

[9] Glasgow Royal Infirm, Dept Pathol, Glasgow G4 0SF, Lanark, Scotland

[10] Univ Gothenburg, Dept Pathol, Gothenburg, Sweden

[11] Tech Univ Munich, Klinikum Rechts Isar, Dept Pathol, D-8000 Munich, Germany

[12] Univ Verona, Dept Pathol, I-37100 Verona, Italy

[13] Univ Lyon, Dept Pathol, Lyon, France

[14] Campus Virchow Klinikum, Dept Internal Med, Berlin, Germany

来源：

VIRCHOWS ARCHIV | 2007年 / 451卷 / 04期

关键词：

neuroendocrine tumors; ileum; appendix; colon; rectum; staging; TNM; grading; mitotic index; Ki-67; index;

D O I：

10.1007/s00428-007-0452-1

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Criteria for the staging and grading of neuroendocrine tumors (NETs) of midgut and hindgut origin were established at the second Consensus Conference in Frascati (Rome) organized by the European Neuroendocrine Tumor Society (ENETS). The proposed tumor-node-metastasis (TNM) classifications are based on the recently published ENETS Guidelines for the Diagnosis and Treatment of gastroenteropancreatic NETs and follow our previous proposal for foregut tumors. The new TNM classifications for NETs of the ileum, appendix, colon, and rectum, and the grading system were designed, discussed, and consensually approved by all conference participants. These proposals need to be validated and are meant to help clinicians in the stratification, treatment and follow-up of patients.

引用

页码：757 / 762

页数：6

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