Predisposing factors and outcome of Staphylococcus aureus bacteremia in neutropenic patients with cancer

被引：54

作者：

González-Barca, E

Carratalà, J

Mykietiuk, A

Fernández-Sevilla, A

Gudiol, F

机构：

[1] Ciutat Sanitaria & Univ Bellvitge, Hosp Duran & Reynals, Inst Catala Oncol, Dept Hematol,Hosp Llobregat, Barcelona 08907, Spain

[2] Ciutat Sanitaria & Univ Bellvitge, Dept Infect Dis, Hosp Llobregat, Barcelona 08907, Spain

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2001年 / 20卷 / 02期

关键词：

D O I：

10.1007/PL00011241

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Staphylococcus aureus caused 30 of 438 (7%) cases of bacteremia in neutropenic patients with cancer during a 10-year study period. Acute leukemia as an underlying disease and severe oral mucositis were more frequent among patients with Staphylococcus aureus bacteremia (57% vs. 33%, P = 0.01, and 32% vs. 12%, P = 0.006, respectively) than among the 151 patients who had gram-negative bacteremia during the same study period. The most frequent source of Staphylococcus aureus bacteremia was the venous catheter (35% vs. 1%; P = 0.00001). Septic metastases were more frequent in patients with Staphylococcus aureus bacteremia (14% vs. 4%, P = 0.03). Attributable mortality was 10% and overall mortality 23%. Staphylococcus aureus bacteremia remains a significant cause of morbidity and mortality in neutropenic patients with cancer.

引用

页码：117 / 119

页数：3

共 16 条

[1] BACTEREMIA DUE TO VIRIDANS STREPTOCOCCI IN NEUTROPENIC PATIENTS - A REVIEW [J].

BOCHUD, PY ;

CALANDRA, T ;

FRANCIOLI, P .

AMERICAN JOURNAL OF MEDICINE, 1994, 97 (03) :256-264

[2] BACTEREMIA DUE TO VIRIDANS STREPTOCOCCUS IN NEUTROPENIC PATIENTS WITH CANCER - CLINICAL SPECTRUM AND RISK-FACTORS [J].

BOCHUD, PY ;

EGGIMAN, P ;

CALANDRA, T ;

VANMELLE, G ;

SAGHAFI, L ;

FRANCIOLI, P .

CLINICAL INFECTIOUS DISEASES, 1994, 18 (01) :25-31

[3] Recent experience with Pseudomonas aeruginosa bacteremia in patients with cancer -: Retrospective analysis of 245 episodes [J].

Chatzinikolaou, I ;

Abi-Said, D ;

Bodey, GP ;

Rolston, KVI ;

Tarrand, JJ ;

Samonis, G .

ARCHIVES OF INTERNAL MEDICINE, 2000, 160 (04) :501-509

[4] PIPERACILLIN-TAZOBACTAM PLUS AMIKACIN VERSUS CEFTAZIDIME PLUS AMIKACIN AS EMPIRIC THERAPY FOR FEVER IN GRANULOCYTOPENIC PATIENTS WITH CANCER [J].

COMETTA, A ;

ZINNER, S ;

DEBOCK, R ;

CALANDRA, T ;

GAYA, H ;

KLASTERSKY, J ;

LANGENAEKEN, J ;

PAESMANS, M ;

VISCOLI, C ;

GLAUSER, MP ;

GIBSON, B ;

SANZ, M ;

HANN, IM ;

FOLLATH, F ;

FATIO, R ;

FERSTER, A ;

VANHOOF, A ;

VANLANDUYT, H ;

ARENDT, V ;

HEMMER, R ;

PEETERMANS, M ;

PADMOS, A ;

SEITANIDES, B ;

HATZIYANNI, M ;

LOPEZ, A ;

PORCELLINI, A ;

GREK, V ;

CABALLERO, D ;

TOGNI, P ;

GALLAGHER, JG ;

GARAVENTA, A ;

MASSIMO, L ;

SUGAR, A ;

LEGRAND, JC ;

OPPENHEIM, B ;

PETRIKKOS, G ;

BEYTOUT, J ;

NIKOSKELAINEN, J ;

SHAPIRO, M ;

ESTAVOYER, JM ;

KERN, W .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (02) :445-452

[5] Monotherapy with meropenem versus combination therapy with ceftazidime plus amikacin as empiric therapy for fever in granulocytopenic patients with cancer [J].

Cometta, AF ;

Calandra, T ;

Gaya, H ;

Zinner, SH ;

deBock, R ;

DelFavero, A ;

Bucaneve, G ;

Crokaert, F ;

Kern, WV ;

Klastersky, J ;

Langenaeken, J ;

Micozzi, A ;

Padmos, A ;

Paesmans, M ;

Viscoli, C ;

Glauser, MP ;

Martino, P ;

Caballero, D ;

Engelhard, D ;

Shapiro, M ;

Castagnola, E ;

Massimo, L ;

Giacchino, R ;

Sanz, M ;

Gigium, M ;

Carotenuto, M ;

Lopez, A ;

Andrien, JM ;

Paulus, R ;

Martino, B ;

Nobile, F ;

Togni, P ;

Ferster, A ;

Cudillo, L ;

Legrand, JC ;

Dinota, A ;

Cajozzo, A ;

Quintini, G ;

MartinezDalmau, A ;

Nosari, A ;

Bucaneve, GP ;

Cometta, A ;

Galazzo, M ;

Giddey, M ;

Bille, J ;

Blaser, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (05) :1108-1115

[6] STAPHYLOCOCCUS-AUREUS BACTEREMIA IN PATIENTS WITH HICKMAN CATHETERS [J].

DUGDALE, DC ;

RAMSEY, PG .

AMERICAN JOURNAL OF MEDICINE, 1990, 89 (02) :137-141

[7] SEPTICEMIA AND SHOCK SYNDROME DUE TO VIRIDANS STREPTOCOCCI - A CASE-CONTROL STUDY OF PREDISPOSING FACTORS [J].

ELTING, LS ;

BODEY, GP ;

KEEFE, BH .

CLINICAL INFECTIOUS DISEASES, 1992, 14 (06) :1201-1207

[8] Nosocomial coagulase-negative staphylococcal infections in bone marrow transplantation recipients with central vein catheter - A 5-year prospective study [J].

Engelhard, D ;

Elishoov, H ;

Strauss, N ;

Naparstek, E ;

Nagler, A ;

Simhon, A ;

Raveh, D ;

Slavin, S ;

Or, R .

TRANSPLANTATION, 1996, 61 (03) :430-434

[9] Prospective study of 288 episodes of bacteremia in neutropenic cancer patients in a single institution [J].

GonzalezBarca, E ;

FernandezSevilla, A ;

Carratala, J ;

Granena, A ;

Gudiol, F .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1996, 15 (04) :291-296

[10] New uses for new and old quinolones and the challenge of resistance [J].

Hooper, DC .

CLINICAL INFECTIOUS DISEASES, 2000, 30 (02) :243-254

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