Angiostatic agents prevent the development of endometriosis-like lesions in the chicken chorioallantoic membrane

被引：77

作者：

Nap, AW

Dunselman, GAJ

Griffioen, AW

Mayo, KH

Evers, JLH

Groothuis, PG

机构：

[1] Maastricht Univ, Dept Pathol, Angiogenesis Lab, Res Inst Growth & Dev, NL-6202 AZ Maastricht, Netherlands

[2] Maastricht Univ, Dept Obstet & Gynaecol, NL-6202 AZ Maastricht, Netherlands

[3] Univ Minnesota, Hlth Sci Ctr, Dept Biochem Mol Biol & Biophys, Minneapolis, MN USA

来源：

FERTILITY AND STERILITY | 2005年 / 83卷 / 03期

关键词：

D O I：

10.1016/j.fertnstert.2004.06.080

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

A prospective study was performed to determine the effects of the angiostatic compounds anti-hVEGF antibody, TNP-470, endostatin, and anginex on the vascularization and on endometriosis-like lesion formation in the chicken chorioallantoic membrane model. Endometriosis-like lesion formation was significantly impaired after treatment with angiostatic agents, which was associated with decreased vessel densities in the surrounding chorioallantoic membrane and more necrosis in the endometriosis-like lesions. (c) 2005 by American Society for Reproductive Medicine.

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收藏

页码：793 / 795

页数：3

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