Platelets with wings:: the maturation of Drosophila integrin biology

被引:57
作者
Brower, DL [1 ]
机构
[1] Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA
关键词
D O I
10.1016/S0955-0674(03)00102-9
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The integrin family of cell surface receptors is strongly conserved in metazoans, making simple invertebrate genetic systems valuable contributors to understanding integrin function. The Drosophila integrins have long served as a paradigm for genetic studies of adhesion proteins during development. Currently, Drosophila experiments are exploring more general aspects of integrin biology. Genetic screens are identifying proteins involved in integrin adhesion complexes and signaling, and structures such as embryonic muscle attachments can be manipulated experimentally to dissect the functions of cytoplasmic components of integrin adhesion sites in whole animals. Drosophila also is beginning to yield some insights into integrin heterodimer structure and function.
引用
收藏
页码:607 / 613
页数:7
相关论文
共 59 条
  • [1] Genetic analysis of olfC demonstrates a role for the position-specific integrins in the olfactory sysfem of Drosophila melanogaster
    Ayyub, C
    Rodrigues, V
    Hasan, G
    Siddiqi, O
    [J]. MOLECULAR AND GENERAL GENETICS, 2000, 263 (03): : 498 - 504
  • [2] Baker SE, 2002, GENETICS, V162, P285
  • [3] Beumer K, 2002, DEVELOPMENT, V129, P3381
  • [4] Beumer KJ, 1999, DEVELOPMENT, V126, P5833
  • [5] Regulating axon branch stability: The role of p190 RhoGAP in repressing a retraction signaling pathway
    Billuart, P
    Winter, CG
    Maresh, A
    Zhao, XS
    Luo, LQ
    [J]. CELL, 2001, 107 (02) : 195 - 207
  • [6] zipper nonmuscle myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation
    Bloor, JW
    Kiehart, DP
    [J]. DEVELOPMENTAL BIOLOGY, 2001, 239 (02) : 215 - 228
  • [7] Bloor JW, 1998, GENETICS, V148, P1127
  • [8] Integrins in development:: Moving on, responding to, and sticking to the extracellular matrix
    Bökel, C
    Brown, NH
    [J]. DEVELOPMENTAL CELL, 2002, 3 (03) : 311 - 321
  • [9] Specific tracheal migration is mediated by complementary expression of cell surface proteins
    Boube, M
    Martin-Bermudo, MD
    Brown, NH
    Casanova, J
    [J]. GENES & DEVELOPMENT, 2001, 15 (12) : 1554 - 1562
  • [10] The PS integrins are required for a regulatory event during Drosophila wing morphogenesis
    Brabant, MC
    Fristrom, D
    Bunch, TA
    Baker, SE
    Brower, DL
    [J]. MORPHOGENESIS: CELLULAR INTERACTIONS, 1998, 857 : 99 - 109