Extranodal nasal type NK/T-cell lymphoma: Elucidating clinical prognostic factors for risk-based stratification of therapy

被引:131
作者
Lee, J
Park, YH
Kim, WS
Lee, SS
Ryoo, BY
Yang, SH
Park, KW
Kang, JH
Park, JO
Lee, SH
Kim, K
Jung, CW
Park, YS
Im, YH
Kang, WK
Lee, MH
Ko, YH
Ahn, YC
Park, K
机构
[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med,Div Hematol & Oncol, Seoul 135710, South Korea
[2] Korea Canc Ctr Hosp, Dept Hematol, Seoul, South Korea
[3] Korea Canc Ctr Hosp, Dept Oncol, Seoul, South Korea
[4] Brody Sch Med, Dept Internal Med, Div Hematol & Oncol, Greenville, NC USA
关键词
NK/T-cell lymphoma; classification; nasal-type;
D O I
10.1016/j.ejca.2005.03.010
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The purpose of this study was to define distinctive clinical features of "nasal" and "nasal-type" NK/T cell lymphomas by assessing prognostic factors. The anatomic definition of extranasal NK/T cell lymphoma has been vague resulting in variable definitions of extranasal sites by different groups. We analysed the clinical behavior of 90 NK/T cell lymphoma patients and attempted to elucidate the prognostic factors for risk-based stratification of therapy. We observed no significant difference between "nasal" and "nasaltype" NK/T cell lymphomas in regards to clinical features and survival using the conventional anatomic classification. We suggest the categorisation of the two subtypes of NK/T cell lymphoma as follows: UNKTL (upper aerodigestive tract NK/T cell lymphoma) including all lymphomas confined to nasal cavity, nasopharynx, and the upper aerodigestive tract and EUNKTL (extra-upper aerodigestive tract NK/T cell lymphoma) group to include all sites other than the UNKTL group. The EUNKTL group in this study had advanced stage at diagnosis, higher LDH, higher IPI score, poorer performance and inferior response to the anthracycline-based chemotherapy with statistical significance. There was a significant difference in survival rate between EUNKTL and UNKTL group (20.0%, 54.0%, respectively, P = 0.0068). More aggressive treatment should be sought for this particular group of patients for EUNKTL patients. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1402 / 1408
页数:7
相关论文
共 24 条
[1]   Quantification of circulating Epstein-Barr virus (EBV) DNA in the diagnosis and monitoring of natural killer cell and EBV-positive lymphomas in immunocompetent patients [J].
Au, WY ;
Pang, A ;
Choy, C ;
Chim, CS ;
Kwong, YL .
BLOOD, 2004, 104 (01) :243-249
[2]   CD56+ hematological neoplasms presenting in the skin: a retrospective analysis of 23 new cases and 130 cases from the literature [J].
Bekkenk, MW ;
Jansen, PM ;
Meijer, CJLM ;
Willemze, R .
ANNALS OF ONCOLOGY, 2004, 15 (07) :1097-1108
[3]   Nonnasal lymphoma expressing the natural killer cell marker CD56: A clinicopathologic study of 49 cases of an uncommon aggressive neoplasm [J].
Chan, JKC ;
Sin, VC ;
Wong, KF ;
Ng, CS ;
Tsang, WYW ;
Chan, CH ;
Cheung, MMC ;
Lau, WH .
BLOOD, 1997, 89 (12) :4501-4513
[4]   Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas [J].
Cheson, BD ;
Horning, SJ ;
Coiffier, B ;
Shipp, MA ;
Fisher, RI ;
Connors, JM ;
Lister, TA ;
Vose, J ;
Grillo-López, A ;
Hagenbeek, A ;
Cabanillas, F ;
Klippensten, D ;
Hiddemann, W ;
Castellino, R ;
Harris, NL ;
Armitage, JO ;
Carter, W ;
Hoppe, R ;
Canellos, GP .
JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (04) :1244-1253
[5]   Primary nasal natural killer cell lymphoma: long-term treatment outcome and relationship with the International Prognostic Index [J].
Chim, CS ;
Ma, SY ;
Au, WY ;
Choy, C ;
Lie, AKW ;
Liang, R ;
Yau, CC ;
Kwong, YL .
BLOOD, 2004, 103 (01) :216-221
[6]   World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee Meeting - Airlie House, Virginia, November 1997 [J].
Harris, NL ;
Jaffe, ES ;
Diebold, J ;
Flandrin, G ;
Muller-Hermelink, HK ;
Vardiman, J ;
Lister, TA ;
Bloomfield, CD .
JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (12) :3835-3849
[7]  
HARRIS NL, 1994, BLOOD, V84, P1361
[8]   Epstein-Barr virus infection of human natural killer cell lines and peripheral blood natural killer cells [J].
Isobe, Y ;
Sugimoto, K ;
Yang, LX ;
Tamayose, K ;
Egashira, M ;
Kaneko, T ;
Takada, K ;
Oshimi, K .
CANCER RESEARCH, 2004, 64 (06) :2167-2174
[9]  
Jaffe ES, 1999, AM J CLIN PATHOL, V111, pS46
[10]   Classification of natural killer (NK) cell and NK-like T-cell malignancies [J].
Jaffe, ES .
BLOOD, 1996, 87 (04) :1207-1210