Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

被引：790

作者：

Semenza, GL ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Johns Hopkins Hosp, Inst Med Genet, Baltimore, MD 21287 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1471-4914(01)02090-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding proteins that mediate adaptive responses to reduced oxygen availability. The HIF-1 beta subunit is constitutively expressed, whereas the HIF-1 alpha subunit is subject to ubiquitination and proteasomal degradation, a process that is inhibited under hypoxic conditions. Recent data indicate that HIF-1 plays major roles in the prevention of myocardial and cerebral ischemia and in the pathogenesis of pulmonary hypertension and cancer. Modulation of HIF-1 activity by genetic or pharmacological means could provide a novel therapeutic approach to these common causes of mortality.

引用

页码：345 / 350

页数：6

共 91 条

[1]

Aebersold DM, 2001, CANCER RES, V61, P2911

[2] Stabilization of wild-type p53 by hypoxia-inducible factor 1α [J].

An, WG ;

Kanekal, M ;

Simon, MC ;

Maltepe, E ;

Blagosklonny, MV ;

Neckers, LM .

NATURE, 1998, 392 (6674) :405-408

[3] Evidence for the involvement of diacylglycerol. kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension [J].

Aragonés, J ;

Jones, DR ;

Martín, S ;

San Juan, MA ;

Alfranca, A ;

Vidal, F ;

Vara, A ;

Mérida, I ;

Landázuri, MO .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (13) :10548-10555

[4] An essential role for p300/CBP in the cellular response to hypoxia [J].

Arany, Z ;

Huang, LE ;

Eckner, R ;

Bhattacharya, S ;

Jiang, C ;

Goldberg, MA ;

Bunn, HF ;

Livingston, DM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (23) :12969-12973

[5]

Bergeron M, 2000, ANN NEUROL, V48, P285, DOI 10.1002/1531-8249(200009)48:3<285::AID-ANA2>3.0.CO

[6]

2-8

[7] Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1 [J].

Bhattacharya, S ;

Michels, CL ;

Leung, MK ;

Arany, ZP ;

Kung, AL ;

Livingston, DM .

GENES & DEVELOPMENT, 1999, 13 (01) :64-75

[8] Levels of hypoxia-inducible factor-1α during breast carcinogenesis [J].

Bos, R ;

Zhong, H ;

Hanrahan, CF ;

Mommers, ECM ;

Semenza, GL ;

Pinedo, HM ;

Abeloff, MD ;

Simons, JW ;

van Diest, PJ ;

van der Wall, E .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2001, 93 (04) :309-314

[9] Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia [J].

Bruick, RK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (16) :9082-9087

[10] Inhibition of TGF-β3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies [J].

Caniggia, I ;

Grisaru-Gravnosky, S ;

Kuliszewsky, M ;

Post, M ;

Lye, SJ .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (12) :1641-1650

← 1 2 3 4 5 6 7 8 9 10 →