The Genomic Threading Database: a comprehensive resource for structural annotations of the genomes from key organisms

被引：32

作者：

McGuffin, LJ ^{[1
]}

Street, SA ^{[1
]}

Bryson, K ^{[1
]}

Sorensen, SA ^{[1
]}

Jones, DT ^{[1
]}

机构：

[1] UCL, Dept Comp Sci, London WC1E 6BT, England

来源：

NUCLEIC ACIDS RESEARCH | 2004年 / 32卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1093/nar/gkh043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Currently, the Genomic Threading Database (GTD) contains structural assignments for the proteins encoded within the genomes of nine eukaryotes and 101 prokaryotes. Structural annotations are carried out using a modified version of GenTHREADER, a reliable fold recognition method. The GenTHREADER annotation jobs are distributed across multiple clusters of processors using grid technology and the predictions are deposited in a relational database accessible via a web interface at http://bioinf.cs.ucl.ac.uk/GTD. Using this system, up to 84% of proteins encoded within a genome can be confidently assigned to known folds with 72% of the residues aligned. On average in the GTD, 64% of proteins encoded within a genome are confidently assigned to known folds and 58% of the residues are aligned to structures.

引用

页码：D196 / D199

页数：4

共 15 条

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