10trans,12cis-linoleic acid reduces apolipoprotein B secretion in HepG2 cells

被引：63

作者：

Yotsumoto, H

Hara, E

Naka, S

Adlof, RO

Emken, EA

Yanagita, T ^{[1
]}

机构：

[1] Saga Univ, Dept Appl Biol Sci, Saga 8408502, Japan

[2] USDA ARS, Natl Ctr Agr Utilizat Res, Peoria, IL 61604 USA

来源：

FOOD RESEARCH INTERNATIONAL | 1998年 / 31卷 / 05期

关键词：

conjugated linoleic acid; trans-Configuration; apolipoprotein B; cholesterol; triglycerides;

D O I：

10.1016/S0963-9969(98)00103-3

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The effects of conjugated linoleic acids (9cis, 11cis-linoleic acid and 10trans, 12cis-linoleic acid) and 9cis, 12cis-linoleic acid on apolipoprotein B (apoB) secretion and on the synthesis of triglycerides and cholesterol were assessed in HepG2 cells. ApoB secretion by cells treated with 10 mu M 10trans, 12cis-linoleic acid for 24 h was decreased markedly when compared with that by cells exposed to 9cis, 12cis-linoleic acid, while cells treated with 9cis, 11cis-linoleic acid were not affected. 10trans, 12cis-linoleic acid inhibited cellular triglyceride and cholesteryl ester synthesis, but 9cis, 11cis-linoleic acid had no effect on triglyceride synthesis. The present study showed that the two conjugated linoleic acids had different influences on apoB and lipid metabolism. Compared with 9cis, 12cis-linoleic acid, 10trans, 12cis-linoleic acid inhibited cellular triglyceride synthesis and reduced apoB secretion. (C) 1999 Canadian Institute of Food Science and Technology. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：403 / 409

页数：7

共 58 条

[1] Apolipoprotein B is intracellularly associated with an ER-60 protease homologue in HepG2 cells [J].