Morphometric evaluation of argyrophilic nucleolar organizer region is useful in predicting long-term survival in squamous cell carcinoma of the lung

被引：20

作者：

Antonangelo, L

Bernardi, FD

Capelozzi, VL

Takagaki, TY

Younes, RN

Yagi, N

Saldiva, PHN

机构：

[1] UNIV SAO PAULO, DEPT PATHOL, LAB EXPT AIR POLLUT, SAO PAULO, BRAZIL

[2] UNIV SAO PAULO, FAC MED, DISCIPLINE PNEUMOL, SAO PAULO, BRAZIL

[3] HOSP AC CARMARGO FUNDACAO ANTONIO PRUDENTE, DEPT THORAC SURG, SAO PAULO, BRAZIL

来源：

CHEST | 1997年 / 111卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

long-term survival; morphometry; nucleolar organizer region; squamous cell carcinoma of the lung;

D O I：

10.1378/chest.111.1.110

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Nucleolar organizer regions identified by means of an argyrophilic technique (AgNOR) were quantified by digital image analysis in 81 patients with squamous cell carcinoma of the lung. Survival rate was modeled as function of AgNOR expression by Cox regression models controlled for staging, histologic grade, age, and sex. Our results indicate that AgNOR expression has a significant prognostic role. Tumors at lower stages have a lower expression of AgNOR than those with more advanced disease. Tumors with high histopathologic grade have a higher expression of AgNOR. Patients with low AgNOR expression presented a higher survival rate than those with higher amounts of AgNOR. The foregoing results strongly encourage the development of prospective trials to assess the real role of AgNOR in determining prognosis in squamous cell carcinoma of the lung.

引用

页码：110 / 114

页数：5

共 23 条

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