Circulating concentrations of folate and vitamin B12 in relation to prostate cancer risk:: Results from the European Prospective Investigation into Cancer and Nutrition study

被引：44

作者：

Johansson, Mattias ^{[1
]}

Appleby, Paul N. ^{[2
]}

Allen, Naomi E. ^{[2
]}

Travis, Ruth C. ^{[2
]}

Roddam, Andrew W. ^{[2
]}

Egevad, Lars ^{[3
]}

Jenab, Mazda ^{[3
]}

Rinaldi, Sabina ^{[3
]}

Kiemeney, Lambertus A. ^{[4
,5
]}

Bueno-de-Mesquita, H. Bas ^{[4
,5
]}

Vollset, Stein Emil ^{[6
]}

Ueland, Per M. ^{[7
]}

Sanchez, Maria-Jose ^{[8
]}

Quiros, J. Ramon ^{[9
]}

Gonzalez, Carlos A. ^{[10
]}

Larranaga, Nerea ^{[11
]}

Chirlaque, Maria Dolores ^{[12
,13
]}

Ardanaz, Eva ^{[14
,15
]}

Sieri, Sabina ^{[16
]}

Palli, Domenico ^{[17
]}

Vineis, Paolo ^{[18
,19
]}

Tumino, Rosario ^{[20
]}

Linseisen, Jakob ^{[21
]}

Kaaks, Rudolf ^{[21
]}

Boeing, Heiner ^{[22
]}

Pischon, Tobias ^{[22
]}

Psaltopouiou, Theodora ^{[23
]}

Trichopouiou, Antonia ^{[23
]}

Trichopoulos, Dimitrios ^{[24
]}

Khaw, Kay-Tee ^{[25
]}

Bingham, Sheila ^{[26
,27
]}

Hallmans, Goran ^{[28
]}

Riboli, Elio ^{[29
]}

Stattin, Par ^{[1
]}

Key, Timothy J. ^{[2
]}

机构：

[1] Umea Univ, Dept Surg & Preoperat Sci, S-90185 Umea, Sweden

[2] Univ Oxford, Epidemiol Unit, Canc Res UK, Oxford, England

[3] Int Agcy Res Canc, F-69372 Lyon, France

[4] Radboud Univ Nijmegen Med Ctr, Dept Epidemiol & Biostat, Nijmegen, Netherlands

[5] Radboud Univ Nijmegen Med Ctr, Dept Urol, Nijmegen, Netherlands

[6] Univ Bergen, Dept Publ Hlth & Primary Hlth Care, Bergen, Norway

[7] Univ Bergen, Inst Med, LOCIS Homocysteine & Related Vitamins, Bergen, Norway

[8] Andalusian Sch Publ Hlth, Granada, Spain

[9] Publ Hlth & Hlth Planning Directorate, Asturias, Spain

[10] Catalan Inst Oncol, Dept Epidemiol, Barcelona, Spain

[11] Publ Hlth Dept Gipuzkoa, Gipuzkoa, Spain

[12] Murcia Hlth Council, Dept Epidemiol, Murcia, Spain

[13] CIBERESP, Murcia, Spain

[14] CIBERESP, Pamplona, Spain

[15] Publ Hlth Inst Navarra, Pamplona, Spain

[16] Natl Canc Inst, Nutr Epidemiol Unit, I-20133 Milan, Italy

[17] Sci Inst Tuscany, Mol & Nutr Epidemiol Unit, Florence, Italy

[18] CSPO, Turin, Italy

[19] Univ Turin, Turin, Italy

[20] Azienda Osped Civile MP Arezzo, Canc Registry, Ragusa, Italy

[21] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany

[22] German Inst Human Nutr, Potsdam, Germany

[23] Univ Athens, Sch Med, Dept Hyg, GR-11527 Athens, Greece

[24] Hellen Hlth Fdn, Athens, Greece

[25] Univ Cambridge, Dept Gerontol, Cambridge, England

[26] Univ Cambridge, MRC Dunn Human Nutr Unit, Dept Publ Hlth & Primary Care, Cambridge, England

[27] Univ Cambridge, MRC Ctr Nutr Epidemiol Canc Prevent & Survival, Dept Publ Hlth & Primary Care, Cambridge, England

[28] Umea Univ Hosp, S-90185 Umea, Sweden

[29] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London, England

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2008年 / 17卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1158/1055-9965.EPI-07-0657

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Determinants of one-carbon metabolism, such as folate and vitamin B-12, have been implicated in cancer development. Previous studies have not provided conclusive evidence for the importance of circulating concentrations of folate and vitamin B-12 in prostate cancer etiology. The aim of the present study was to investigate the relationship between prostate cancer risk and circulating concentrations of folate and vitamin B-12 in a large prospective cohort. Methods: We analyzed circulating concentrations of folate and vitamin B-12 in 869 cases and 1,174 controls, individually matched on center, age, and date of recruitment, nested within the European Prospective Investigation into Cancer and Nutrition cohort. Relative risks (RR) for prostate cancer were estimated using conditional logistic regression models. Results: Overall, no significant associations were observed for circulating concentrations of folate (P-trend = 0.62) or vitamin B-12 (P-trend = 0.21) with prostate cancer risk. RRs for a doubling in folate and vitamin B-12 concentrations were 1.03 [95% confidence interval (95% CI), 0.92-1.16] and 1.12 (95% CI, 0.94-1.35), respectively. In the subgroup of cases diagnosed with advanced stage prostate cancer, elevated concentrations of vitamin B-12 were associated with increased risk (RR for a doubling in concentration, 1.69; 95% CI, 1.05-2.72, P-trend = 0.03). No other subgroup analyses resulted in a statistically significant association. Conclusion: This study does not provide strong support for an association between prostate cancer risk and circulating concentrations of folate or vitamin B-12-Elevated concentrations of vitamin B-12 may be associated with an increased risk for advanced stage prostate cancer, but this association requires examination in other large prospective studies.

引用

页码：279 / 285

页数：7

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