A new view on hypocortisolism

被引：928

作者：

Fries, E ^{[1
]}

Hesse, J ^{[1
]}

Hellhammer, J ^{[1
]}

Hellhammer, DH ^{[1
]}

机构：

[1] Univ Trier, Dept Psychobiol, D-54290 Trier, Germany

来源：

PSYCHONEUROENDOCRINOLOGY | 2005年 / 30卷 / 10期

关键词：

hypocortisolism; cortisol; allostatic load index; developmental model; protective effects;

D O I：

10.1016/j.psyneuen.2005.04.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Low cortisol levels have been observed in patients with different stress-related disorders such as chronic fatigue syndrome, fibromyalgia, and posttraumatic stress disorder. Data suggest that these disorders are characterized by a symptom triad of enhanced stress sensitivity, pain, and fatigue. This overview will present data on the development, mechanisms and consequences of hypocortisolism on different bodily systems. We propose that the phenomenon of hypocortisotism may occur after a prolonged period of hyperactivity of the hypothalamic-pituitary-adrenal axis due to chronic stress as illustrated in an animal model. Further evidence suggests that despite symptoms such as pain, fatigue and high stress sensitivity, hypocortisolism may also have beneficial effects on the organism. This assumption wilt be underlined by some studies suggesting protective effects of hypocortisolism for the individual. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：1010 / 1016

页数：7

相关论文

共 62 条

[1] Pain and PTSD symptoms in female veterans [J].

Asmundson, GJG ;

Wright, KD ;

Stein, MB .

EUROPEAN JOURNAL OF PAIN, 2004, 8 (04) :345-350

[2] Musculoskeletal manifestations and autoantibody profile in 90 hepatitis C virus infected Israeli patients [J].

Buskila, D ;

Shnaider, A ;

Neumann, L ;

Lorber, M ;

Zilberman, D ;

Hilzenrat, N ;

Kuperman, OJ ;

Sikuler, E .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 1998, 28 (02) :107-113

[3] Chronic widespread pain and fibromyalgia: what we know, and what we need to know [J].

Clauw, DJ ;

Crofford, LJ .

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY, 2003, 17 (04) :685-701

[4] Chronic pain and fatigue syndromes: Overlapping clinical and neuroendocrine features and potential pathogenic mechanisms [J].

Clauw, DJ ;

Chrousos, GP .

NEUROIMMUNOMODULATION, 1997, 4 (03) :134-153

[5] Prevalence of post-traumatic stress disorder in fibromyalgia patients: Overlapping syndromes or post-traumatic fibromyalgia syndrome? [J].

Cohen, H ;

Neumann, L ;

Haiman, Y ;

Matar, MA ;

Press, J ;

Buskila, D .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2002, 32 (01) :38-50

[6] Posttraumatic stress disorder in female veterans - Association with self-reported health problems and functional impairment [J].

Dobie, DJ ;

Kivlahan, DR ;

Maynard, C ;

Bush, KR ;

Davis, TM ;

Bradley, KA .

ARCHIVES OF INTERNAL MEDICINE, 2004, 164 (04) :394-400

[7] Relationship of physical symptoms to posttraumatic stress disorder among veterans seeking care for Gulf War-related health concerns [J].

Engel, CC ;

Liu, X ;

McCarthy, BD ;

Miller, RF ;

Ursano, R .

PSYCHOSOMATIC MEDICINE, 2000, 62 (06) :739-745

[8] Posttraumatic stress symptomatology is associated with unexplained illness attributed to Persian Gulf War military service [J].

Ford, JD ;

Campbell, KA ;

Storzbach, D ;

Binder, LM ;

Anger, WK ;

Rohlman, DS .

PSYCHOSOMATIC MEDICINE, 2001, 63 (05) :842-849

[9] Glucocorticoids and inflammation revisited: The state of the art [J].

Franchimont, D ;

Kino, T ;

Galon, J ;

Meduri, GU ;

Chrousos, G .

NEUROIMMUNOMODULATION, 2002, 10 (05) :247-260

[10] The relationship between symptoms of post-traumatic stress disorder and pain, affective disturbance and disability among patients with accident and non-accident related pain [J].

Geisser, ME ;

Roth, RS ;

Bachman, JE ;

Eckert, TA .

PAIN, 1996, 66 (2-3) :207-214

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