Temperature modulation of the stereochemistry of enzymatic catalysis: Prospects for exploitation

被引：195

作者：

Phillips, RS

机构：

[1] UNIV GEORGIA,DEPT BIOCHEM & MOLEC BIOL,ATHENS,GA 30602

[2] UNIV GEORGIA,CTR METALLOENZYME STUDIES,ATHENS,GA 30602

来源：

TRENDS IN BIOTECHNOLOGY | 1996年 / 14卷 / 01期

关键词：

D O I：

10.1016/0167-7799(96)80908-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The use of physical variables to control the stereochemical outcome of enzyme-catalysed reactions is of great interest in biocatalysis. The effects of temperature on stereochemistry were not understood and fully appreciated until recently. This article indicates how temperature can influence the stereochemistry of enzymatic reactions, and reviews the prospects for future applications of temperature modulation of the stereochemical course of enzymatic reactions.

引用

收藏

页码：13 / 16

页数：4

相关论文

共 14 条

[1] TEMPERATURE AND DMSO INCREASE THE ENANTIOSELECTIVITY OF HYDROLYSIS OF METHYL ALKYL DIMETHYLMALONATES CATALYZED BY PIG-LIVER ESTERASE [J].

ANDRADE, MAC ;

ANDRADE, FAC ;

PHILLIPS, RS .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1991, 1 (07) :373-376

[2] THE EFFECT OF DIMETHYLSULFOXIDE ON THE ENANTIOSELECTIVITY IN THE PIG-LIVER ESTERASE CATALYZED-HYDROLYSIS OF DIALKYLATED PROPANEDIOIC ACID DIMETHYL ESTERS [J].

BJORKLING, F ;

BOUTELJE, J ;

GATENBECK, S ;

HULT, K ;

NORIN, T ;

SZMULIK, P .

BIOORGANIC CHEMISTRY, 1986, 14 (02) :176-181

[3] HOW CAN THE SOLVENT AFFECT ENZYME ENANTIOSELECTIVITY [J].

FITZPATRICK, PA ;

KLIBANOV, AM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (08) :3166-3171

[4] THERMOSTABLE ENZYMES IN ORGANIC-SYNTHESIS .2. ASYMMETRIC REDUCTION OF KETONES WITH ALCOHOL-DEHYDROGENASE FROM THERMOANAEROBIUM-BROCKII [J].

KEINAN, E ;

HAFELI, EK ;

SETH, KK ;

LAMED, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (01) :162-169

[5] ENZYMES IN ORGANIC-SYNTHESIS .35. STEREOSELECTIVE PIG-LIVER ESTERASE CATALYZED HYDROLYZES OF 3-SUBSTITUTED GLUTARATE DIESTERS - OPTIMIZATION OF ENANTIOMERIC EXCESS VIA REACTION CONDITIONS CONTROL [J].

LAM, LKP ;

HUI, RAHF ;

JONES, JB .

JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (11) :2047-2050

[6] LIPASE-CATALYZED TRANSESTERIFICATIONS USING 2,2,2-TRIFLUOROETHYL BUTYRATE - EFFECT OF TEMPERATURE ON RATE OF REACTION AND ENANTIOSELECTIVITY [J].

PARMAR, VS ;

PRASAD, AK ;

SINGH, PK ;

GUPTA, S .

TETRAHEDRON-ASYMMETRY, 1992, 3 (11) :1395-1398

[7] EFFECTS OF SUBSTRATE STRUCTURE AND TEMPERATURE ON THE STEREOSPECIFICITY OF SECONDARY ALCOHOL-DEHYDROGENASE FROM THERMOANAEROBACTER-ETHANOLICUS [J].

PHAM, VT ;

PHILLIPS, RS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (09) :3629-3632

[8] TEMPERATURE-DEPENDENT ENANTIOSPECIFICITY OF SECONDARY ALCOHOL-DEHYDROGENASE FROM THERMOANAEROBACTER-ETHANOLICUS [J].

PHAM, VT ;

PHILLIPS, RS ;

LJUNGDAHL, LG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (05) :1935-1936

[9] TEMPERATURE EFFECTS ON STEREOCHEMISTRY OF ENZYMATIC-REACTIONS [J].

PHILLIPS, RS .

ENZYME AND MICROBIAL TECHNOLOGY, 1992, 14 (05) :417-419

[10]

Prelog V., 1964, PURE APPL CHEM, V9, P119, DOI DOI 10.1351/PAC196409010119