Protease-Activatable Collagen Targeting Based on Protein Cyclization

被引：7

作者：

Breurken, Monika ^{[1
]}

Lempens, Edith H. M. ^{[1
]}

Merkx, Maarten ^{[1
]}

机构：

[1] Eindhoven Univ Technol, Biol Chem Lab, Dept Biomed Engn, NL-5600 MB Eindhoven, Netherlands

来源：

CHEMBIOCHEM | 2010年 / 11卷 / 12期

关键词：

collagen; matrix metalloproteinases (MMP); molecular imaging; molecular recognition; protein engineering; CELL-PENETRATING PEPTIDES; MATRIX-METALLOPROTEINASE; BINDING; CANCER; MODEL; PROBE;

D O I：

10.1002/cbic.201000223

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

(Chemical Presented) Threading collagen through a protein needle: The collagen-binding protein CNA35 operates by wrapping itself around the collagen triple helix. By connecting the N and C termini through an MMP recognition sequence, a dual-specific MMP-sensitive collagen-targeting ligand is obtained that can be used for imaging extracellular matrix turnover. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1665 / 1668

页数：4

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