A new application of a peptide library to identify selective interaction between small peptides in an attempt to develop recognition molecules toward protein surfaces

Combinatorial technologies with the use of a solid-phase pentapeptide library and the magnetic beads covalently bound with the target nonapeptide (1) were applied to search for recognition peptides toward the target sequence (1) which constitutes an extracelluar part of the dopamine D2 receptor. Several pentapeptides have been identified to exhibit high binding affinities toward the target peptide (1) in an aqueous solution.