New functions of aminoacyl-tRNA synthetases beyond translation

被引：280

作者：

Guo, Min ^{[1
,2
,3
]}

Yang, Xiang-Lei ^{[1
,2
]}

Schimmel, Paul ^{[1
,2
]}

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[3] Scripps Florida, Scripps Res Inst, Dept Canc Biol, Jupiter, FL 33458 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2010年 / 11卷 / 09期

基金：

美国国家卫生研究院;

关键词：

NONCANONICAL FUNCTION; EXTRARIBOSOMAL FUNCTIONS; MOONLIGHTING PROTEINS; CYTOKINE ACTIVITIES; GENETIC-CODE; COMPLEX; DOMAIN; ANGIOGENESIS; COMBINATION; MUTATIONS;

D O I：

10.1038/nrm2956

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Over the course of evolution, eukaryotic aminoacyl-tRNA synthetases (aaRSs) progressively incorporated domains and motifs that have no essential connection to aminoacylation reactions. Their accretive addition to virtually all aaRSs correlates with the progressive evolution and complexity of eukaryotes. Based on recent experimental findings focused on a few of these additions and analysis of the aaRS proteome, we propose that they are markers for aaRS-associated functions beyond translation.

引用

页码：668 / 674

页数：7

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