Notch-mediated restoration of regenerative potential to aged muscle

被引：803

作者：

Conboy, IM

Conboy, MJ

Smythe, GM

Rando, TA ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

[2] VA Palo Alto Hlth Care Syst, GRECC, Palo Alto, CA 94304 USA

[3] VA Palo Alto Hlth Care Syst, Serv Neurol, Palo Alto, CA 94304 USA

来源：

SCIENCE | 2003年 / 302卷 / 5650期

关键词：

D O I：

10.1126/science.1087573

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A hallmark of aging is diminished regenerative potential of tissues, but the mechanism of this decline is unknown. Analysis of injured muscle revealed that, with age, resident precursor cells ( satellite cells) had a markedly impaired propensity to proliferate and to produce myoblasts necessary for muscle regeneration. This was due to insufficient up-regulation of the Notch ligand Delta and, thus, diminished activation of Notch in aged, regenerating muscle. Inhibition of Notch impaired regeneration of young muscle, whereas forced activation of Notch restored regenerative potential to old muscle. Thus, Notch signaling is a key determinant of muscle regenerative potential that declines with age.

引用

页码：1575 / 1577

页数：3

共 23 条

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