Diaminopurine-acridine heterodimers for specific recognition of abasic site containing DNA. Influence on the biological activity of the position of the linker on the purine ring

被引：16

作者：

Alarcon, K

Demeunynck, M

Lhomme, J

Carrez, D

Croisy, A

机构：

[1] Univ Grenoble 1, CNRS, UMR 5616, LEDSS, F-38041 Grenoble 9, France

[2] Ctr Univ Orsay, Lab Raymond Latarjet, Inst Curie Rech, INSERM,U350, F-91405 Orsay, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(01)00310-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three acridine-diaminopurine heterodimers tethered by a linker containing an N,N ' -substituted guanidine were prepared. The molecules differ by the site of introduction of the linker on the 2,6-diaminopurine. The interactions of the new heterodimers with abasic site containing oligonucleotide were compared, and their cytotoxicity was measured in the presence or absence of the antitumor alkylating agent BCNU. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：1855 / 1858

页数：4

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