CATIE and CUtLASS: can we handle the truth?

被引：90

作者：

Lewis, Shon ^{[1
]}

Lieberman, Jeffrey ^{[2
,3
,4
,5
]}

机构：

[1] Univ Manchester, Neurosci & Psychiat Unit, Manchester M13 9PL, Lancs, England

[2] Columbia Univ, Coll Phys & Surg, Dept Psychiat, New York, NY 10027 USA

[3] New York State Psychiat Inst & Hosp, New York, NY 10032 USA

[4] New York Presbyterian Hosp, New York, NY 10021 USA

[5] Columbia Univ, Med Ctr, New York, NY 10027 USA

来源：

BRITISH JOURNAL OF PSYCHIATRY | 2008年 / 192卷 / 03期

关键词：

D O I：

10.1192/bjp.bp.107.037218

中图分类号：

R749 [精神病学];

学科分类号：

100205 [精神病与精神卫生学];

摘要：

Two large, non-commercial clinical trials comparing first- and second-generation antipsychotic drugs for people with chronic schizophrenia in the US and UK have shown unexpected results. in general, the newer drugs were no more effective or better tolerated than the older drugs. Clozapine outperformed other second-gene ration drugs. The implications are considered. Declaration of interest S.L. is the Chief investigator of the CUtLASS study and J.L. is the Chief Investigator of the CATIE study, S.L. has received honoraria from several pharmaceutical companies. J.L. has received research funding from several pharmaceutical companies.

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页码：161 / 163

页数：3

相关论文

共 20 条

[1]

Lower risk for tardive dyskinesia associated with second-generation antipsychotics: A systematic review of 1-year studies [J].

Correll, CU ;

Leucht, S ;

Kane, JM .

AMERICAN JOURNAL OF PSYCHIATRY, 2004, 161 (03) :414-425

[2]

Cost-effectiveness of first- v. second-generation antipsychotic drugs: results from a randomised controlled trial in schizophrenia responding poorly to previous therapy [J].

Davies, L. M. ;

Lewis, S. ;

Jones, P. B. ;

Barnes, T. R. E. ;

Gaughran, F. ;

Hayhurst, K. ;

Markwick, A. ;

Lloyd, H. .

BRITISH JOURNAL OF PSYCHIATRY, 2007, 191 :14-22

[3]

A meta-analysis of the efficacy of second-generation antipsychotics [J].

Davis, JM ;

Chen, N ;

Glick, ID .

ARCHIVES OF GENERAL PSYCHIATRY, 2003, 60 (06) :553-564

[4]

Effectiveness of switching antipsychotic medications [J].

Essock, Susan M. ;

Covell, Nancy H. ;

Davis, Sonia M. ;

Stroup, T. Scott ;

Rosenheck, Robert A. ;

Lieberman, Jeffrey A. .

AMERICAN JOURNAL OF PSYCHIATRY, 2006, 163 (12) :2090-2095

[5]

Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis [J].

Geddes, J ;

Freemantle, N ;

Harrison, P ;

Bebbington, P .

BRITISH MEDICAL JOURNAL, 2000, 321 (7273) :1371-1376

[6]

Studies of cognitive change in patients with schizophrenia following novel antipsychotic treatment [J].

Harvey, PD ;

Keefe, RSE .

AMERICAN JOURNAL OF PSYCHIATRY, 2001, 158 (02) :176-184

[7]

Why olanzapine beats risperidone, risperidone beats quetiapine, and quetiapine beats olanzapine: An exploratory analysis of head-to-head comparison studies of second-generation antipsychotics [J].

Heres, S ;

Davis, J ;

Maino, K ;

Jetzinger, E ;

Kissling, W ;

Leucht, S .

AMERICAN JOURNAL OF PSYCHIATRY, 2006, 163 (02) :185-194

[8]

Randomized controlled trial of the effect on quality of life of second- vs first-generation antipsychotic drugs in schizophrenia - Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1) [J].

Jones, Peter B. ;

Barnes, Thomas R. E. ;

Davies, Linda ;

Dunn, Graham ;

Lloyd, Helen ;

Hayhurst, Karen P. ;

Murray, Robin M. ;

Markwick, Alison ;

Lewis, Shon W. .

ARCHIVES OF GENERAL PSYCHIATRY, 2006, 63 (10) :1079-U6

[9]

KANE J, 1988, ARCH GEN PSYCHIAT, V45, P789

[10]

Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE trial [J].

Keefe, Richard S. E. ;

Bilder, Robert M. ;

Davis, Sonia M. ;

Harvey, Philip D. ;

Palmer, Barton W. ;

Gold, James M. ;

Meltzer, Herbert Y. ;

Green, Michael F. ;

Capuano, George ;

Stroup, T. Scott ;

McEvoy, Joseph P. ;

Swartz, Marvin S. ;

Roscnheck, Robert A. ;

Perkins, Diana O. ;

Davis, Clarence E. ;

Hsiao, John K. ;

Lieberman, Jcffrey A. .

ARCHIVES OF GENERAL PSYCHIATRY, 2007, 64 (06) :633-647