Microbial transformation of artemether

被引：21

作者：

Abourashed, EA

Hufford, CD

机构：

[1] UNIV MISSISSIPPI,DEPT PHARMACOGNOSY,UNIVERSITY,MS 38677

[2] UNIV MISSISSIPPI,PHARMACEUT SCI RES INST,UNIVERSITY,MS 38677

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 03期

关键词：

D O I：

10.1021/np960060b

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Microbial transformation of the semisynthetic sesquiterpene artedether, using Cunninghamella elegans and Streptomyces lavendulae, resulted in the isolation of five microbial metabolites that were characterized on the basis of their H-1 and C-13 NMR spectral data. These metabolites were identified as 9 beta-hydroxyartemether, 9 alpha-hydroxyartemether, ring-rearranged 9 beta-hydroxyartemether, 3 alpha-hydroxydeoxyartemether, and 14-hydroxyartemether. The latter three compounds are new and are being reported here for the first time.

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页码：251 / 253

页数：3

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