Evidence for osteocyte regulation of bone homeostasis through RANKL expression

被引：1437

作者：

Nakashima, Tomoki ^{[1
,2
,3
]}

Hayashi, Mikihito ^{[1
,2
,3
]}

Fukunaga, Takanobu ^{[1
,2
,3
]}

Kurata, Kosaku ^{[4
]}

Oh-hora, Masatsugu ^{[1
,2
,3
]}

Feng, Jian Q. ^{[5
]}

Bonewald, Lynda F. ^{[6
]}

Kodama, Tatsuhiko ^{[7
]}

Wutz, Anton ^{[8
]}

Wagner, Erwin F. ^{[9
]}

Penninger, Josef M. ^{[10
]}

Takayanagi, Hiroshi ^{[1
,2
,3
,11
]}

机构：

[1] Tokyo Med & Dent Univ, Dept Cell Signaling, Grad Sch Med & Dent Sci, Bunkyo Ku, Tokyo, Japan

[2] Japan Sci & Technol Agcy, Exploratory Res Adv Technol Program, Takayanagi Osteonetwork Project, Bunkyo Ku, Tokyo, Japan

[3] Global Ctr Excellence Program, Int Res Ctr Mol Sci Tooth & Bone Dis, Bunkyo Ku, Tokyo, Japan

[4] Kyushu Univ, Fac Engn, Dept Mech Engn, Nishi Ku, Fukuoka 812, Japan

[5] Baylor Coll Dent, Dept Biomed Sci, Texas A&M Hlth Sci Ctr, Dallas, TX 75246 USA

[6] Univ Missouri, Dept Oral Biol, Kansas City, MO 64110 USA

[7] Univ Tokyo, Res Ctr Adv Sci & Technol, Dept Mol Biol & Med, Tokyo, Japan

[8] Univ Cambridge, Dept Biochem, Wellcome Trust Ctr Stem Cell Res, Cambridge CB2 1QW, England

[9] Spanish Natl Canc Ctr, Genes Dev & Dis Grp, Banco Bilbao Vizcaya Argentaria Fdn, Canc Cell Biol Program, Madrid, Spain

[10] Austrian Acad Sci, Inst Mol Biotechnol, A-1010 Vienna, Austria

[11] Univ Western Australia, Ctr Orthopaed Res, Sch Surg, Perth, WA 6009, Australia

来源：

NATURE MEDICINE | 2011年 / 17卷 / 10期

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

OSTEOBLASTS; MECHANISMS; RECEPTOR; MOUSE;

D O I：

10.1038/nm.2452

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Osteocytes embedded in bone have been postulated to orchestrate bone homeostasis by regulating both bone-forming osteoblasts and bone-resorbing osteoclasts. We find here that purified osteocytes express a much higher amount of receptor activator of nuclear factor-kappa B ligand (RANKL) and have a greater capacity to support osteoclastogenesis in vitro than osteoblasts and bone marrow stromal cells. Furthermore, the severe osteopetrotic phenotype that we observe in mice lacking RANKL specifically in osteocytes indicates that osteocytes are the major source of RANKL in bone remodeling in vivo.

引用

页码：1231 / 1234

页数：4

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