Monozygotic twins reveal germline contribution to allelic expression differences

被引：24

作者：

Cheung, Vivian G. ^{[1
,2
,3
]}

Bruzel, Alan ^{[2
]}

Burdick, Joshua T. ^{[4
]}

Morley, Michael ^{[3
]}

Devlin, James L. ^{[1
]}

Spielman, Richard S. ^{[1
]}

机构：

[1] Univ Penn, Dept Genet, Philadelphia, PA 19104 USA

[2] Univ Penn, Howard Hughes Med Inst, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Pediat, Philadelphia, PA 19104 USA

[4] Univ Penn, Genom & Computat Biol Grad Program, Philadelphia, PA 19104 USA

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 2008年 / 82卷 / 06期

关键词：

D O I：

10.1016/j.ajhg.2008.05.003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Variation in the level of gene expression is a major determinant of a cell's function and characteristics. Common allelic variants of genes can be expressed at different levels and thus contribute to phenotypic diversity. We have measured allelic expression differences at heterozygous loci in monozygotic twins and in unrelated individuals. We show that the extent of differential allelic expression is highly similar within monozygotic twin pairs for many loci, implying that allelic differences in gene expression are under genetic control. We also show that even subtle departures from equal allelic expression are often genetically determined.

引用

页码：1357 / 1360

页数：4

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