Factors stimulating bone formation

被引：47

作者：

Lind, M ^{[1
]}

Bünger, C ^{[1
]}

机构：

[1] Aarhus Univ Hosp, Orthopaed Res Lab, DK-8000 Aarhus C, Denmark

来源：

EUROPEAN SPINE JOURNAL | 2001年 / 10卷 / Suppl 2期

关键词：

bone healing; bone graft; growth factors; stimulation; stem cells; gene therapy;

D O I：

10.1007/s005860100269

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aim of this review is to describe major approaches for stimulating bone healing and to review other factors affecting bone healing. Spinal bone fusion after surgery is a demanding process requiring optimal conditions for clinical success. Bone formation and healing can be enhanced through various methods. Experimental studies have revealed an array of stimulative measures. These include biochemical stimulation by use of hormones and growth factors, physical stimulation through mechanical and electromagnetic measures, and bone grafting by use of bone tissue or bone substitutes. Newer biological techniques such as stem cell transplantation and gene therapy can also be used to stimulate bone healing. Apart from bone transplantation, clinical experience with the many stimulation modalities is limited. Possible areas for clinical use of these novel methods are discussed.

引用

页码：S102 / S109

页数：8

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