A microcapillary system for simultaneous, parallel microwave-assisted synthesis

被引：82

作者：

Comer, E ^{[1
]}

Organ, MG ^{[1
]}

机构：

[1] York Univ, Dept Chem, N York, ON M3J 1P3, Canada

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2005年 / 11卷 / 24期

关键词：

combinatorial chemistry; cross-coupling; microreactors; microwaves; parallel synthesis;

D O I：

10.1002/chem.200500820

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A continuous flow, microwave-assisted, parallel-capillary microreactor has been developed. Libraries of drug candidates were prepared on the milligram scale with this reactor by injecting plugs of reagents from separate syringes into common reaction capillaries, thereby producing discrete compounds in excellent yield and purity. Microwave irradiation provides the necessary energy that existing room-temperature microreactor technology lacks for higher activation barrier transformations, producing the required amounts of desired compounds in minutes or less.

引用

页码：7223 / 7227

页数：5

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