5-Amino-4-aryl-2,2-dimethyl-1,3-dioxans: application as chiral NMR shift reagents and derivatizing agents for acidic compounds

被引：22

作者：

Enders, D ^{[1
]}

Thomas, CR ^{[1
]}

Runsink, J ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0957-4166(99)00003-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The use of (4S,5S)-5-amino-2,2-dimethyl-4-phenyl-1,3-dioxan (ADPD) and (4R,5R)-5-amino-(4'-biphenyl)-2,2-dimethyl-1,3-dioxan (ABDD) as chiral solvating agents (CSA) for the ee determination of compounds bearing an acidic proton by means of H-1 NMR spectroscopy is demonstrated. In addition, based on the well known rigid conformation of these amines, ADPD and ABDD are suitable as chiral derivatizing agents (CDAs) in order to determine absolute configurations. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：323 / 326

页数：4

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