Low preoperative serum cholesterol level is associated with aggressive pathologic features and poor cancer-specific survival in patients with surgically treated renal cell carcinoma

被引：23

作者：

Kang, Ho Won ^{[1
,2
]}

Seo, Sung Pil ^{[1
,2
]}

Kim, Won Tae ^{[1
,2
]}

Yun, Seok Joong ^{[1
,2
]}

Lee, Sang-Cheol ^{[1
,2
]}

Kim, Wun-Jae ^{[1
,2
]}

Hwang, Eu Chang ^{[3
]}

Kang, Seok Ho ^{[4
]}

Hong, Sung-Hoo ^{[5
]}

Chung, Jinsoo ^{[6
]}

Kwon, Tae Gyun ^{[7
]}

Kim, Hyeon Hoe ^{[8
]}

Kwak, Cheol ^{[8
]}

Byun, Seok-Soo ^{[9
]}

Kim, Yong-June ^{[1
,2
]}

机构：

[1] Chungbuk Natl Univ, Dept Urol, Coll Med, 1st Chungdae Ro, Cheongju 28644, Chungbuk, South Korea

[2] Chungbuk Natl Univ Hosp, Dept Urol, Cheongju, South Korea

[3] Chonnam Natl Univ, Dept Urol, Hwasun Hosp, Gwangju, Jeonnam, South Korea

[4] Korea Univ, Dept Urol, Sch Med, Seoul, South Korea

[5] Catholic Univ Korea, Dept Urol, Coll Med, Seoul, South Korea

[6] Natl Canc Ctr, Dept Urol, Goyang, South Korea

[7] Kyungpook Natl Univ, Dept Urol, Coll Med, Daegu, South Korea

[8] Seoul Natl Univ, Dept Urol, Coll Med, Seoul, South Korea

[9] Seoul Natl Univ, Dept Urol, Bundang Hosp, 166 Gumi Ro, Seongnam 463707, Kyunggi Do, South Korea

来源：

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY | 2018年 / 23卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Renal cell carcinoma; Nephrectomy; Cholesterol; Prognosis; Survival; STATUS CONUT SCORE; BODY-MASS INDEX; PROGNOSTIC-SIGNIFICANCE; METABOLIC SYNDROME; DIABETES-MELLITUS; CLINICAL BENEFIT; METAANALYSIS; NEPHRECTOMY; GUIDELINE; OUTCOMES;

D O I：

10.1007/s10147-017-1172-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The prognostic implications of preoperative serum total cholesterol (TC) level in patients with renal cell carcinoma (RCC) remain poorly understood. We investigated the prognostic role of preoperative serum TC in patients with surgically treated RCC from a large, multi-institutional Korean collaboration. A database of 3064 patients with RCC who underwent radical or partial nephrectomy between 1999 and 2011 at eight academic centers was analyzed. Preoperative serum TC levels were measured in fasting blood samples. Low preoperative serum TC level was associated with aggressive tumor characteristics, including large tumor size, advanced stage, high nuclear grade, lymph node involvement, and sarcomatous differentiation (all P < 0.001). Low TC level was associated with poor recurrence-free or cancer-specific survival (CSS) in the entire cohort, whereas the significance of the association changed after stratification by disease stage and histologic subtype. Multivariate Cox regression analysis showed that preoperative TC, as a continuous or categorical variable, was an independent predictor of CSS. Preoperative low serum TC level was associated with aggressive tumor characteristics and poor CSS in patients with surgically treated RCC. Preoperative TC may provide additional guidance regarding the choice of therapeutic strategies to improve prognosis.

引用

页码：142 / 150

页数：9

共 30 条

[1]

Hypertension and clinical benefit of bevacizumab in the treatment of advanced renal cell carcinoma [J].