Involvement of cytokines, chemokines and adhesion molecules in opioid analgesia

被引：31

作者：

Rittner, HL ^{[1
]}

Stein, C ^{[1
]}

机构：

[1] Univ Med Berlin, Charite, Klin Anasthesiol & Operat Intensivmed, D-12200 Berlin, Germany

来源：

EUROPEAN JOURNAL OF PAIN | 2005年 / 9卷 / 02期

关键词：

inflammatory pain; cytokines; chemokines; opioid peptides; peripheral analgesia;

D O I：

10.1016/j.ejpain.2004.05.009

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Tissue destruction is accompanied by an inflammatory reaction. The inflammatory reaction leads to activation of nociceptors and the sensation of pain. Several mediators are responsible for pain and hyperalgesia in inflammation including cytokines, chemokines, nerve growth factor as well as bradykinin, prostaglandins and ATP. Simulatenously however, analgesic mediators are secreted: opioid peptides, somatostatin, endocannabinoids and certain cytokines. Opioid peptides secreted from immune cells are so far the best studied peptides in peripheral inflammatory pain control. This system is hampered for example by anti-adhesion molecule treatment. Novel immunosuppressive drugs for treatment of autoimmune disease targetting cytokines, chemokines or adhesion molecules should therefore be evaluated for potential harmful effects on pain. (c) 2004 European Federation of Chapters of the International Association for the Study of Pain. Published by Elsevier Ltd. All rights reserved.

引用

页码：109 / 112

页数：4

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