Levodopa stability in solution: Time course, environmental effects, and practical recommendations for clinical use

被引：34

作者：

Pappert, EJ

Buhrfiend, C

Lipton, JW

Carvey, PM

Stebbins, GT

Goetz, CG

机构：

[1] Department of Neurological Sciences, Movement Disorders Section, Rush-Presbyt.-St. Luke's Med. Center, Chicago, IL

[2] Department of Neurological Sciences, Rush-Presbyt.-St. Luke's Med. Center, Chicago, IL 60612

来源：

MOVEMENT DISORDERS | 1996年 / 11卷 / 01期

关键词：

levodopa; liquid; Parkinson's disease; temperature; light; ascorbate;

D O I：

10.1002/mds.870110106

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We defined the temporal stability characteristics of levodopa/carbidopa (LD/CD) solution, and determined the effects of temperature, ascorbate, and light on LD stability over 7 days. At room temperature and without ascorbate, LD levels significantly declined by 48 h. Ascorbate prolonged stability to 72 h. Refrigeration and freezing prevented a significant decline in LD levels for the full 7 days. Light or darkness had no effect on stability. LD/CD solution, if made daily, requires no special handling and longer stability is maintained with ascorbate, refrigeration, or freezing.

引用

页码：24 / 26

页数：3

共 10 条

[1] SUSTAINED ENTERAL ADMINISTRATION OF LEVODOPA INCREASES AND INTERRUPTED INFUSION DECREASES LEVODOPA DOSE REQUIREMENTS [J].

CEDARBAUM, JM ;

SILVESTRI, M ;

KUTT, H .

NEUROLOGY, 1990, 40 (06) :995-997

[2] MOTOR FLUCTUATIONS IN PARKINSONS-DISEASE - CENTRAL PATHOPHYSIOLOGICAL MECHANISMS .1. [J].

FABBRINI, G ;

MOURADIAN, MM ;

JUNCOS, JL ;

SCHLEGEL, J ;

MOHR, E ;

CHASE, TN .

ANNALS OF NEUROLOGY, 1988, 24 (03) :366-371

[3] ON-OFF PHENOMENON WITH LEVODOPA THERAPY IN PARKINSONISM - CLINICAL AND PHARMACOLOGIC CORRELATIONS AND EFFECT OF INTRAMUSCULAR PYRIDOXINE [J].

FAHN, S .

NEUROLOGY, 1974, 24 (05) :431-441

[4] CONTROLLED-RELEASE CARBIDOPA LEVODOPA (CR4-SINEMET) IN PARKINSONS-DISEASE PATIENTS WITH AND WITHOUT MOTOR FLUCTUATIONS [J].

GOETZ, CG ;

TANNER, CM ;

SHANNON, KM ;

CARROLL, VS ;

KLAWANS, HL ;

CARVEY, PM ;

GILLEY, D .

NEUROLOGY, 1988, 38 (07) :1143-1146

[5] ORAL LEVODOPA CARDIBOPA SOLUTION VERSUS TABLETS IN PARKINSONS PATIENTS WITH SEVERE FLUCTUATIONS - A PILOT-STUDY [J].

KURTH, MC ;

TETRUD, JW ;

IRWIN, I ;

LYNESS, WH ;

LANGSTON, JW .

NEUROLOGY, 1993, 43 (05) :1036-1039

[6] FLUCTUATIONS IN PLASMA LEVODOPA AND MOTOR-RESPONSES WITH LIQUID AND TABLET LEVODOPA CARBIDOPA [J].

METMAN, LV ;

HOFF, J ;

MOURADIAN, MM ;

CHASE, TN .

MOVEMENT DISORDERS, 1994, 9 (04) :463-465

[7] MOTOR FLUCTUATIONS IN PARKINSONS-DISEASE - CENTRAL PATHOPHYSIOLOGICAL MECHANISMS .2. [J].

MOURADIAN, MM ;

JUNCOS, JL ;

FABBRINI, G ;

SCHLEGEL, J ;

BARTKO, JJ ;

CHASE, TN .

ANNALS OF NEUROLOGY, 1988, 24 (03) :372-378

[8] THE ON OFF PHENOMENON IN PARKINSONS-DISEASE - RELATION TO LEVODOPA ABSORPTION AND TRANSPORT [J].

NUTT, JG ;

WOODWARD, WR ;

HAMMERSTAD, JP ;

CARTER, JH ;

ANDERSON, JL .

NEW ENGLAND JOURNAL OF MEDICINE, 1984, 310 (08) :483-488

[9]

SINGH A, 1993, NEUROLOGY, V43, pA197

[10] SIMULTANEOUS DETERMINATION OF 3,4-DIHYDROXYPHENYLALANINE, 5-HYDROXYTRYPTOPHAN, DOPAMINE, 4-HYDROXY-3-METHOXYPHENYLALANINE, NOREPINEPHRINE, 3,4-DIHYDROXYPHENYLACETIC ACID, HOMOVANILLIC-ACID, SEROTONIN, AND 5-HYDROXYINDOLEACETIC ACID IN RAT CEREBROSPINAL-FLUID AND BRAIN BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTIO, [J].

WAGNER, J ;

VITALI, P ;

PALFREYMAN, MG ;

ZRAIKA, M ;

HUOT, S .

JOURNAL OF NEUROCHEMISTRY, 1982, 38 (05) :1241-1254

← 1 →