Thioredoxin and its related molecules: Update 2005

被引:144
作者
Nakamura, H [1 ]
机构
[1] Kyoto Univ Hosp, Thioredoxin Project, Dept Expt Therapeut, Translat Res Ctr,Sakyo Ku, Kyoto 6068607, Japan
关键词
D O I
10.1089/ars.2005.7.823
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Studies on thioredoxin (Trx) and its related molecules have expanded dramatically recently. Proteins that share the similar active-site sequence, -Cys-Xxx-Yyy-Cys-, are called the Trx family, and the number of Trx family members is increasing. Trx reductase, which reduces oxidized Trx in cooperation with NADPH, has three isoforms, and peroxiredoxin, which is Trx-dependent peroxidase, has six isoforms. In addition to a role as an antioxidant, Trx and its related molecules play crucial roles in the redox regulation of signal transduction. The classical cytosolic Trx1 and truncated Trx80 are released from cells. Plasma/serum levels of Trx1 are good markers for oxidative stress. Exogenous Trx1 shows cytoprotective and antfinflammatory effects and has a good potential for clinical application. This is an update review on Trx and its related molecules.
引用
收藏
页码:823 / 828
页数:6
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