Thioredoxin and its related molecules: Update 2005

被引：144

作者：

Nakamura, H ^{[1
]}

机构：

[1] Kyoto Univ Hosp, Thioredoxin Project, Dept Expt Therapeut, Translat Res Ctr,Sakyo Ku, Kyoto 6068607, Japan

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2005年 / 7卷 / 5-6期

关键词：

D O I：

10.1089/ars.2005.7.823

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Studies on thioredoxin (Trx) and its related molecules have expanded dramatically recently. Proteins that share the similar active-site sequence, -Cys-Xxx-Yyy-Cys-, are called the Trx family, and the number of Trx family members is increasing. Trx reductase, which reduces oxidized Trx in cooperation with NADPH, has three isoforms, and peroxiredoxin, which is Trx-dependent peroxidase, has six isoforms. In addition to a role as an antioxidant, Trx and its related molecules play crucial roles in the redox regulation of signal transduction. The classical cytosolic Trx1 and truncated Trx80 are released from cells. Plasma/serum levels of Trx1 are good markers for oxidative stress. Exogenous Trx1 shows cytoprotective and antfinflammatory effects and has a good potential for clinical application. This is an update review on Trx and its related molecules.

引用

页码：823 / 828

页数：6

共 71 条

[1] [Anonymous], SPECIAL PUBLICATIONS
[2] Positional cloning of the combined hyperlipidemia gene Hyplip1
Bodnar, JS
Chatterjee, A
Castellani, LW
Ross, DA
Ohmen, J
Cavalcoli, J
Wu, CY
Dains, KM
Catanese, J
Chu, M
Sheth, SS
Charugundla, K
Demant, P
West, DB
de Jong, P
Lusis, AJ
[J]. NATURE GENETICS, 2002, 30 (01) : 110 - 116
[3] Glutathionylation of human thioredoxin: A possible crosstalk between the glutathione and thioredoxin systems
Casagrande, S
Bonetto, V
Fratelli, M
Gianazza, E
Eberini, I
Massignan, T
Salmona, M
Chang, G
Holmgren, A
Ghezzi, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (15) : 9745 - 9749
[4] ERdJ5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress
Cunnea, PM
Miranda-Vizuete, A
Bertoli, G
Simmen, T
Damdimopoulos, AE
Hermann, S
Leinonen, S
Huikko, MP
Gustafsson, JÅ
Sitia, R
Spyrou, G
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (02) : 1059 - 1066
[5] Thioredoxin regulation of ischemic preconditioning
Das, DK
[J]. ANTIOXIDANTS & REDOX SIGNALING, 2004, 6 (02) : 405 - 412
[6] Thioredoxin system in premature and newborn biology
Das, KC
[J]. ANTIOXIDANTS & REDOX SIGNALING, 2004, 6 (01) : 177 - 184
[7] Glutaredoxins: Glutathione-dependent redox enzymes with functions far beyond a simple thioredoxin backup system
Fernandes, AP
Holmgren, A
[J]. ANTIOXIDANTS & REDOX SIGNALING, 2004, 6 (01) : 63 - 74
[8] Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69
Haendeler, J
Hoffmann, J
Tischler, V
Berk, BC
Zeiher, AM
Dimmeler, S
[J]. NATURE CELL BIOLOGY, 2002, 4 (10) : 743 - 749
[9] Antioxidant effects of statins via S-nitrosylation and activation of thioredoxin in endothelial cells -: A novel vasculoprotective function of statins
Haendeler, J
Hoffmann, J
Zeiher, AM
Dimmeler, S
[J]. CIRCULATION, 2004, 110 (07) : 856 - 861
[10] Intravenous administration of thioredoxin decreases brain damage following transient focal cerebral ischemia in mice
Hattori, I
Takagi, Y
Nakamura, H
Nozaki, K
Bai, H
Kondo, N
Sugino, T
Nishimura, M
Hashimoto, N
Yodoi, J
[J]. ANTIOXIDANTS & REDOX SIGNALING, 2004, 6 (01) : 81 - 87

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