In vivo measurement of [11C]verapamil kinetics in human tissues

被引：26

作者：

Hendrikse, NH

de Vries, EGE

Franssen, EJF

Vaalburg, W

van der Graaf, WTA

机构：

[1] Univ Groningen Hosp, PET Ctr, NL-9700 RB Groningen, Netherlands

[2] Univ Groningen Hosp, Dept Med Oncol, NL-9700 RB Groningen, Netherlands

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 2001年 / 56卷 / 11期

关键词：

C-11]verapamil kinetics; lung extraction; positron emission tomography;

D O I：

10.1007/s002280000253

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Objective: To evaluate [C-11]verapamil kinetics in humans. Methods: After intravenous injection of [C-11]verapamil (370 MBq, specific activity >1600 GBq/mmol), kinetics were evaluated in five cancer patients using positron emission tomography (PET). Results: One hour after injection, accumulation of [C-11] in lungs, heart and tumour was 43.0%, 1.3% and 0.9% of the injected verapamil dose, respectively. Half-lives of [C-11]verapamil in these tissues were 46.2 min, 73.8 min and 23.7 min, respectively. Conclusions: Intravenously administered [C-11] was mainly extracted by the lungs. Transport of a [C-11]ve-rapamil bolus out of solid tumour tissue is relatively fast.

引用

页码：827 / 829

页数：3