Molecular mechanisms of interspecies transmission and pathogenicity of influenza viruses: Lessons from the 2009 pandemic

被引:37
作者
Klenk, Hans D. [1 ]
Garten, Wolfgang [1 ]
Matrosovich, Mikhail [1 ]
机构
[1] Univ Marburg, Inst Virol, D-3550 Marburg, Germany
关键词
2009; pandemic; host range; influenza virus; pathogenicity; HEMAGGLUTININ CLEAVAGE SITE; LOWER RESPIRATORY-TRACT; TO-HUMAN TRANSMISSION; A VIRUS; H5N1; INFLUENZA; NS1; PROTEIN; GENETIC-CHARACTERIZATION; RECEPTOR SPECIFICITY; POLYMERASE COMPLEX; ENHANCED VIRULENCE;
D O I
10.1002/bies.201000118
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The emergence of the 2009 H1N1 virus pandemic was unexpected, since it had been predicted that the next pandemic would be caused by subtype H5N1. We also had to learn that a pandemic does not necessarily require the introduction of a new virus subtype into the human population, but that it may result from antigenic shift within the same subtype. The new variant was derived from human and animal viruses by genetic reassortment in the pig, supporting the concept that this animal is the mixing vessel for the generation of new human influenza viruses. Although it is generally believed that the 2009 outbreak was mild, there have been severe cases particularly among the young and the middle-aged. Pathogenicity and host range are determined to a large extent by the polymerase, the haemagglutinin and the NS1 protein of influenza A viruses. There is evidence that mutations of these proteins may change the pathogenicity of the new virus.
引用
收藏
页码:180 / 188
页数:9
相关论文
共 120 条
[1]   History of highly pathogenic avian influenza [J].
Alexander, D. J. ;
Brown, I. H. .
REVUE SCIENTIFIQUE ET TECHNIQUE-OFFICE INTERNATIONAL DES EPIZOOTIES, 2009, 28 (01) :19-38
[2]   Changes in the haemagglutinin and the neuraminidase genes prior to the emergence of highly pathogenic H7N1 avian influenza viruses in Italy [J].
Banks, J ;
Speidel, ES ;
Moore, E ;
Plowright, L ;
Piccirillo, A ;
Capua, I ;
Cordioli, P ;
Fioretti, A ;
Alexander, DJ .
ARCHIVES OF VIROLOGY, 2001, 146 (05) :963-973
[3]   Cleavage of Influenza Virus Hemagglutinin by Airway Proteases TMPRSS2 and HAT Differs in Subcellular Localization and Susceptibility to Protease Inhibitors [J].
Boettcher-Friebertshaeuser, Eva ;
Freuer, Catharina ;
Sielaff, Frank ;
Schmidt, Sarah ;
Eickmann, Markus ;
Uhlendorff, Jennifer ;
Steinmetzer, Torsten ;
Klenk, Hans-Dieter ;
Garten, Wolfgang .
JOURNAL OF VIROLOGY, 2010, 84 (11) :5605-5614
[4]  
BOSMAN A, 2004, 63094000 RIVM
[5]   Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium [J].
Böttcher, Eva ;
Matrosovich, Tatyana ;
Beyerle, Michaela ;
Klenk, Hans-Dieter ;
Garten, Wolfgang ;
Matrosovich, Mikhail .
JOURNAL OF VIROLOGY, 2006, 80 (19) :9896-9898
[6]   The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus [J].
Brass, Abraham L. ;
Huang, I-Chueh ;
Benita, Yair ;
John, Sinu P. ;
Krishnan, Manoj N. ;
Feeley, Eric M. ;
Ryan, Bethany J. ;
Weyer, Jessica L. ;
van der Weyden, Louise ;
Fikrig, Erol ;
Adams, David J. ;
Xavier, Ramnik J. ;
Farzan, Michael ;
Elledge, Stephen J. .
CELL, 2009, 139 (07) :1243-1254
[7]   Portrait of a year-old pandemic [J].
Butler, Declan .
NATURE, 2010, 464 (7292) :1112-1113
[8]   Interspecies transmission of an H7N3 influenza virus from wild birds to intensively reared domestic poultry in Italy [J].
Campitelli, L ;
Mogavero, E ;
De Marco, MA ;
Delogu, M ;
Puzelli, S ;
Frezza, F ;
Facchini, M ;
Chiapponi, C ;
Foni, E ;
Cordioli, P ;
Webby, R ;
Barigazzi, G ;
Webster, RG ;
Donatelli, I .
VIROLOGY, 2004, 323 (01) :24-36
[9]   Continued circulation in China of highly pathogenic avian influenza viruses encoding the hemagglutinin gene associated with the 1997 H5N1 outbreak in poultry and humans [J].
Cauthen, AN ;
Swayne, DE ;
Schultz-Cherry, S ;
Perdue, ML ;
Suarez, DL .
JOURNAL OF VIROLOGY, 2000, 74 (14) :6592-6599
[10]   Establishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic control [J].
Chen, H ;
Smith, GJD ;
Li, KS ;
Wang, J ;
Fan, XH ;
Rayner, JM ;
Vijaykrishna, D ;
Zhang, JX ;
Zhang, LJ ;
Guo, CT ;
Cheung, CL ;
Xu, KM ;
Duan, L ;
Huang, K ;
Qin, K ;
Leung, YHC ;
Wu, WL ;
Lu, HR ;
Chen, Y ;
Xia, NS ;
Naipospos, TSP ;
Yuen, KY ;
Hassan, SS ;
Bahri, S ;
Nguyen, TD ;
Webster, RG ;
Peiris, JSM ;
Guan, Y .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (08) :2845-2850