The kinesin Klp2 mediates polarization of interphase microtubules in fission yeast

被引:44
作者
Carazo-Salas, RE
Antony, C
Nurse, P
机构
[1] Canc Res UK, London Res Inst, Cell Cycle Lab, London WC2A 1PX, England
[2] European Mol Biol Lab, D-69117 Heidelberg, Germany
[3] Rockefeller Univ, New York, NY 10021 USA
关键词
D O I
10.1126/science.1113465
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Fission yeast (Schizosaccharomyces pombe) cells grow longitudinally in a manner dependent on a polarized distribution of their interphase microtubules. We found that this distribution required sliding of microtubules toward the cell center along preexisting microtubules. This sliding was mediated by the minus end-directed kinesin motor Klp2, which helped microtubules to become properly organized with plus ends predominantly oriented toward the cell ends and minus ends toward the cell center. Thus, interphase microtubules in the fission yeast require motor activities for their proper organization.
引用
收藏
页码:297 / 300
页数:4
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